Individual Research Projects

Each of the seven PROSPR Research Centers was funded to conduct 3 single-center research projects centered around a common theme. In addition, multisite projects have also been conducted by PROSPR investigators after approval by the PROSPR Steering Committee, using data from a central data repository housed at the Statistical Coordinating Center. View the table below to learn more about the single-center research projects.

Principal Investigator(s) Institution Aims
Katrina Armstrong, MD, MSCE
Mitchell Schnall, MD, PhD
University of Pennsylvania
  • Compare the false positive rates of 3D vs. 2D digital mammography.
  • Evaluate the ability of an imaging biomarker to reduce false positive rates.
  • Test risk communication strategies.
Anna Tosteson, ScD
Tracy Onega, PhD
Jennifer Haas, MD, MS
Geisel School of Medicine at Dartmouth and Brigham and Women’s Hospital
  • Map screening process for heterogeneous health care systems and develop electronic health record (EHR)-integrated tools for improving screening processes.
  • Develop an EHR-integrated module to generate tailored risk assessments and screening recommendations.
  • Compare the effectiveness of care processes for established and emerging modalities.
Brian Sprague, PhD
Donald Weaver, MD
University of Vermont
  • Develop prognostic markers for personalized management of ductal carcinoma in situ (DCIS).
  • Identify molecular, morphologic, radiologic, and tumor microenvironment markers that predict progression of DCIS to invasive disease.
Cosette Wheeler, PhD University of New Mexico
  • Compare self-collection versus provider-directed human papillomavirus primary screening.
  • Analyze statewide cervical screening, diagnosis and treatment failures.
  • Compare the effectiveness of alternative interventions using decision-analytic approaches across the cervical cancer care continuum.
Carolyn Rutter, PhD Kaiser Permanente Washington Health Research Institute
  • Identify low-risk groups that might benefit from less intensive screening.
  • Evaluate the potential mortality impact of risk-based screening.
Celette Sugg Skinner, PhD, MA
Ethan Halm, MD, MPH
University of Texas Southwestern
  • Optimize risk-based screening in a large safety-net system.
  • Identify clinic and health system factors associated with screening adoption in practices that serve vulnerable populations.
Douglas Corley, MD, PhD, MPH
Chyke Doubeni, MD, MPH
T.R. Levin, MD
Ann Zauber, PhD
Kaiser Foundation Research Institute
  • Identify failures in the screening process and develop corrective strategies.
  • Compare benefits, harms, and effectiveness of alternative screening strategies, including those based on individualized risk.