PROSPR I Publications

Multi-Organ, Multi-Site

Armstrong K, Kim JJ, Halm EA, Ballard RM, Schnall MD. Using lessons from breast, cervical, and colorectal cancer screening to inform the development of lung cancer screening programs. Cancer. 2016 May 1;122(9):1338-42. doi: 10.1002/cncr.29937. Epub 2016 Feb 29. [View AbstractExternal Web Site Policy]

Beaber EF, Kim JJ, Schapira MM, Tosteson AN, Zauber AG, Geiger AM, Kamineni A, Weaver DL, Tiro JA; Population-based Research Optimizing Screening through Personalized Regimens Consortium. Unifying screening processes within the PROSPR consortium: a conceptual model for breast, cervical, and colorectal cancer screening. J Natl Cancer Inst. 2015 May 7;107(6):djv120. doi: 10.1093/jnci/djv120. Print 2015 Jun. [View AbstractExternal Web Site Policy]

Corley DA, Haas JS, Kobrin S. Reducing Variation in the "Standard of Care" for Cancer Screening: Recommendations From the PROSPR Consortium. JAMA. 2016 May 17;315(19):2067-8. doi: 10.1001/jama.2016.3067. [View AbstractExternal Web Site Policy]

Haas JS, Sprague BL, Klabunde CN, Tosteson AN, Chen JS, Bitton A, Beaber EF, Onega T, Kim JJ, MacLean CD, Harris K, Yamartino P, Howe K, Pearson L, Feldman S, Brawarsky P, Schapira MM; PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) Consortium. Provider Attitudes and Screening Practices Following Changes in Breast and Cervical Cancer Screening Guidelines. J Gen Intern Med. 2016 Jan;31(1):52-9. doi: 10.1007/s11606-015-3449-5. [View AbstractExternal Web Site Policy]

Kim JJ, Tosteson AN, Zauber AG, Sprague BL, Stout NK, Alagoz O, Trentham-Dietz A, Armstrong K, Pruitt SL, Rutter CM; Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium. Cancer Models and Real-world Data: Better Together. J Natl Cancer Inst. 2015 Nov 3;108(2). pii: djv316. doi: 10.1093/jnci/djv316. Print 2016 Feb. [View AbstractExternal Web Site Policy]

McCarthy AM, Kim JJ, Beaber EF, Zheng Y, Burnett-Hartman A, Chubak J, Ghai NR, McLerran D, Breen N, Conant EF, Geller BM, Green BB, Klabunde CN, Inrig S, Skinner CS, Quinn VP, Haas JS, Schnall M, Rutter CM, Barlow WE, Corley DA, Armstrong K, Doubeni CA; PROSPR consortium. Follow-Up of Abnormal Breast and Colorectal Cancer Screening by Race/Ethnicity. Am J Prev Med. 2016 Oct;51(4):507-12. doi: 10.1016/j.amepre.2016.03.017. Epub 2016 Apr 28. [View AbstractExternal Web Site Policy]

Schapira MM, Sprague BL, Klabunde CN, Tosteson AN, Bitton A, Chen JS, Beaber EF, Onega T, MacLean CD, Harris K, Howe K, Pearson L, Feldman S, Brawarsky P, Haas JS; PROSPR consortium. Inadequate Systems to Support Breast and Cervical Cancer Screening in Primary Care Practice. J Gen Intern Med. 2016 Oct;31(10):1148-55. doi: 10.1007/s11606-016-3726-y. Epub 2016 Jun 1. [View AbstractExternal Web Site Policy]

Tosteson AN, Beaber EF, Tiro J, Kim J, McCarthy AM, Quinn VP, Doria-Rose VP, Wheeler CM, Barlow WE, Bronson M, Garcia M, Corley DA, Haas JS, Halm EA, Kamineni A, Rutter CM, Tosteson TD, Trentham-Dietz A, Weaver DL; PROSPR consortium. Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium. J Gen Intern Med. 2016 Apr;31(4):372-9. doi: 10.1007/s11606-015-3552-7. [View Abstract>External Web Site Policy]

Multi-Site (Non-Cancer Specific)

Balasubramanian BA, Garcia MP, Corley DA, Doubeni CA, Haas JS, Kamineni A, Quinn VP, Wernli K, Zheng Y, Skinner CS. Racial/ethnic differences in obesity and comorbidities between safety-net- and non safety-net integrated health systems. Medicine (Baltimore). 2017 Mar;96(11):e6326. doi: 10.1097/MD.0000000000006326. [View AbstractExternal Web Site Policy

Chen JS, Sprague BL, Klabunde CN, Tosteson AN, Bitton A, Onega T, MacLean CD, Harris K, Schapira MM, Haas JS; PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) Consortium. Take the money and run? Redemption of a gift card incentive in a clinician survey. BMC Med Res Methodol. 2016 Feb 24;16:25. doi: 10.1186/s12874-016-0126-2. [View AbstractExternal Web Site Policy]

Cervical Cancer

Multi-Site Studies

Gage JC, Hunt WC, Schiffman M, Katki HA, Cheung LA, Myers O, Cuzick J, Wentzensen N, Kinney W, Castle PE, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. Similar Risk Patterns After Cervical Screening in Two Large U.S. Populations: Implications for Clinical Guidelines. Obstet Gynecol. 2016 Dec;128(6):1248-1257. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: University of New Mexico

Bosch FX, Broker TR, Forman D, Moscicki AB, Gillison ML, Doorbar J, Stern PL, Stanley M, Arbyn M, Poljak M, Cuzick J, Castle PE, Schiller JT, Markowitz LE, Fisher WA, Canfell K, Denny LA, Franco EL, Steben M, Kane MA, Schiffman M, Meijer CJ, Sankaranarayanan R, Castellsagué X, Kim JJ, Brotons M, Alemany L, Albero G, Diaz M, de Sanjosé S; authors of ICO Monograph Comprehensive Control of HPV Infections and Related Diseases Vaccine Volume 30, Supplement 5, 2012. Comprehensive control of human papillomavirus infections and related diseases. Vaccine 2013 Dec 31;31 Suppl 7:H1-31. doi: 10.1016/j.vaccine.2013.10.003. [View AbstractExternal Web Site Policy]

Burger EA, Kim JJ. The value of improving failures within a cervical cancer screening program: an example from Norway. Int J Cancer. 2014 Oct 15;135(8):1931-9. doi: 10.1002/ijc.28838. Epub 2014 Mar 20. [View AbstractExternal Web Site Policy]

Burger EA, Sy S, Nygård M, Kristiansen IS, Kim JJ Prevention of HPV-related cancers in Norway: cost-effectiveness of expanding the HPV vaccination program to include pre-adolescent boys. PLoS One. 2014 Mar 20;9(3):e89974. doi: 10.1371/journal.pone.0089974. eCollection 2014. [View AbstractExternal Web Site Policy]

Campos NG, Burger EA, Sy S, Sharma M, Schiffman M, Rodriguez AC, Hildesheim A, Herrero R, Kim JJ. An updated natural history model of cervical cancer: derivation of model parameters. Am J Epidemiol. 2014 Sep 1;180(5):545-55. doi: 10.1093/aje/kwu159. Epub 2014 Jul 31. [View AbstractExternal Web Site Policy]

Cuzick J, Myers O, Hunt WC, Saslow D, Castle PE, Kinney W, Waxman A, Robertson M, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. Human papillomavirus testing 2007-2012: co-testing and triage utilization and impact on subsequent clinical management. Int J Cancer. 2015 Jun 15;136(12):2854-63. doi: 10.1002/ijc.29337. Epub 2014 Dec 1. [View AbstractExternal Web Site Policy]

Gage JC, Hunt WC, Schiffman M, Katki HA, Cheung LC, Cuzick J, Myers O, Castle PE, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. Risk Stratification Using Human Papillomavirus Testing among Women with Equivocally Abnormal Cytology: Results from a State-Wide Surveillance Program. Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):36-42. doi: 10.1158/1055-9965.EPI-15-0669. Epub 2015 Oct 30. [View AbstractExternal Web Site Policy]

Kim JJ, Campos NG, Sy S, Burger EA, Cuzick J, Castle PE, Hunt WC, Waxman A, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. Inefficiencies and High-Value Improvements in U.S. Cervical Cancer Screening Practice: A Cost-Effectiveness Analysis. Ann Intern Med. 2015 Oct 20;163(8):589-97. doi: 10.7326/M15-0420. Epub 2015 Sep 29. [View AbstractExternal Web Site Policy]

Kim JJ. Practice-based evidence for primary HPV testing in the United States. J Natl Cancer Inst. 2014 Jul 18;106(8). pii: dju213. doi: 10.1093/jnci/dju213. Print 2014 Aug. [View AbstractExternal Web Site Policy]

Kinney W, Hunt WC, Dinkelspiel H, Robertson M, Cuzick J, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. Cervical excisional treatment of young women: a population-based study. Gynecol Oncol. 2014 Mar;132(3):628-35. doi: 10.1016/j.ygyno.2013.12.037. Epub 2014 Jan 4. [View AbstractExternal Web Site Policy]

McDonald YJ, Schwind M, Goldberg DW, Lampley A, Wheeler CM. An analysis of the process and results of manual geocode correction. Geospat Health. 2017 May 11;12(1):526. doi: 10.4081/gh.2017.526. [View AbstractExternal Web Site Policy]

Breast Cancer

Single Organ, Multi-Site Studies

Beaber EF, Tosteson AN, Haas JS, Onega T, Sprague BL, Weaver DL, McCarthy AM, Doubeni CA, Quinn VP, Skinner CS, Zauber AG, Barlow WE. Breast cancer screening initiation after turning 40 years of age within the PROSPR consortium. Breast Cancer Res Treat. 2016 Nov;160(2):323-331. Epub 2016 Sep 24. [View AbstractExternal Web Site Policy]

Conant EF, Beaber EF, Sprague BL, Herschorn SD, Weaver DL, Onega T, Tosteson AN, McCarthy AM, Poplack SP, Haas JS, Armstrong K, Schnall MD, Barlow WE. Breast cancer screening using tomosynthesis in combination with digital mammography compared to digital mammography alone: a cohort study within the PROSPR consortium. Breast Cancer Res Treat . 2016 Feb;156(1):109-16. doi: 10.1007/s10549-016-3695-1. Epub 2016 Mar 1. [View AbstractExternal Web Site Policy]

Freer PE, Slanetz PJ, Haas JS, Tung NM, Hughes KS, Armstrong K, Semine AA, Troyan SL, Birdwell RL. Breast cancer screening in the era of density notification legislation: summary of 2014 Massachusetts experience and suggestion of an evidence-based management algorithm by multi-disciplinary expert panel. Breast Cancer Res Treat. 2015 Sep;153(2):455-64. doi: 10.1007/s10549-015-3534-9. Epub 2015 Aug 20. Review. [View AbstractExternal Web Site Policy]

Goodrich ME, Weiss J, Onega T, Balch SL, Buist DS, Kerlikowske K, Henderson LM, Hubbard RA; Breast Cancer Surveillance Consortium. The Role of Preoperative Magnetic Resonance Imaging in the Assessment and Surgical Treatment of Interval and Screen-Detected Breast Cancer in Older Women. Breast J. 2016 Nov;22(6):616-622. doi: 10.1111/tbj.12651. Epub 2016 Aug 23. [View AbstractExternal Web Site Policy]

Haas JS, Barlow WE, Schapira MM, MacLean CD, Klabunde CN, Sprague BL, Beaber EF, Chen JS, Bitton A, Onega T, Harris K, Tosteson AN; PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) consortium. Primary Care Providers' Beliefs and Recommendations and Use of Screening Mammography by their Patients. J Gen Intern Med. 2017 Apr;32(4):449-457. doi: 10.1007/s11606-016-3973-y. Epub 2017 Jan 9. [View AbstractExternal Web Site Policy]

Haas JS, Hill DA, Wellman RD, Hubbard RA, Lee CI, Wernli KJ, Stout NK, Tosteson AN, Henderson LM, Alford-Teaster JA, Onega TL. Disparities in the use of screening magnetic resonance imaging of the breast in community practice by race, ethnicity, and socioeconomic status. Cancer. 2016 Feb 15;122(4):611-7. doi: 10.1002/cncr.29805. Epub 2015 Dec 28. [View AbstractExternal Web Site Policy]

Henderson LM, O'Meara ES, Braithwaite D, Onega T; Breast Cancer Surveillance Consortium. Performance of digital screening mammography among older women in the United States. Cancer. 2015 May 1;121(9):1379-86. doi: 10.1002/cncr.29214. Epub 2014 Dec 23. [View AbstractExternal Web Site Policy]

Hubbard RA, O'Meara ES, Henderson LM, Hill D, Braithwaite D, Haas JS, Lee CI, Sprague BL, Alford-Teaster J, Tosteson AN, Wernli KJ, Onega T. Multilevel factors associated with long-term adherence to screening mammography in older women in the U.S. Prev Med. 2016 Aug;89:169-77. doi: 10.1016/j.ypmed.2016.05.034. Epub 2016 May 31. [View AbstractExternal Web Site Policy]

Jackson SL, Frederick PD, Pepe MS, Nelson HD, Weaver DL, Allison KH, Carney PA, Geller BM, Tosteson AN, Onega T, Elmore JG. Diagnostic Reproducibility: What Happens When the Same Pathologist Interprets the Same Breast Biopsy Specimen at Two Points in Time? Ann Surg Oncol. 2017 May;24(5):1234-1241. doi: 10.1245/s10434-016-5695-0. Epub 2016 Dec 2. [View AbstractExternal Web Site Policy]

Kerlikowske K, Zhu W, Tosteson AN, Sprague BL, Tice JA, Lehman CD, Miglioretti DL; Breast Cancer Surveillance Consortium. Identifying women with dense breasts at high risk for interval cancer: a cohort study. Ann Intern Med. 2015 May 19;162(10):673-81. doi: 10.7326/M14-1465. [View AbstractExternal Web Site Policy]

Lee CI, Cevik M, Alagoz O, Sprague BL, Tosteson AN, Miglioretti DL, Kerlikowske K, Stout NK, Jarvik JG, Ramsey SD, Lehman CD. Comparative effectiveness of combined digital mammography and tomosynthesis screening for women with dense breasts. Radiology. 2015 Mar;274(3):772-80. doi: 10.1148/radiol.14141237. Epub 2014 Oct 28. [View AbstractExternal Web Site Policy]

Lehman CD, Arao RF, Sprague BL, Lee JM, Buist DS, Kerlikowske K, Henderson LM, Onega T, Tosteson AN, Rauscher GH, Miglioretti DL. National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr;283(1):49-58. doi: 10.1148/radiol.2016161174. Epub 2016 Dec 5. [View AbstractExternal Web Site Policy]

Lehman CD, Wellman RD, Buist DS, Kerlikowske K, Tosteson AN, Miglioretti DL; Breast Cancer Surveillance Consortium. Diagnostic Accuracy of Digital Screening Mammography With and Without Computer-Aided Detection. JAMA Intern Med. 2015 Nov;175(11):1828-37. doi: 10.1001/jamainternmed.2015.5231. [View AbstractExternal Web Site Policy]

Mandelblatt JS, Stout NK, Schechter CB, van den Broek JJ, Miglioretti DL, Krapcho M, Trentham-Dietz A, Munoz D, Lee SJ, Berry DA, van Ravesteyn NT, Alagoz O, Kerlikowske K, Tosteson AN, Near AM, Hoeffken A, Chang Y, Heijnsdijk EA, Chisholm G, Huang X, Huang H, Ergun MA, Gangnon R, Sprague BL, Plevritis S, Feuer E, de Koning HJ, Cronin KA. Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies. Ann Intern Med. 2016 Feb 16;164(4):215-25. doi: 10.7326/M15-1536. Epub 2016 Jan 12. [View AbstractExternal Web Site Policy]

Miglioretti DL, Zhu W, Kerlikowske K, Sprague BL, Onega T, Buist DS, Henderson LM, Smith RA; Breast Cancer Surveillance Consortium. Breast Tumor Prognostic Characteristics and Biennial vs Annual Mammography, Age, and Menopausal Status. JAMA Oncol. 2015 Nov;1(8):1069-77. doi: 10.1001/jamaoncol.2015.3084. [View AbstractExternal Web Site Policy]

Onega T, Weaver DL, Frederick PD, Allison KH, Tosteson ANA, Carney PA, Geller BM, Longton GM, Nelson HD, Oster NV, Pepe MS, Elmore JG. The diagnostic challenge of low-grade ductal carcinoma in situ. Eur J Cancer. 2017 Jul;80:39-47. doi: 10.1016/j.ejca.2017.04.013. Epub 2017 May 20. [View AbstractExternal Web Site Policy]

Onega T, Lee CI, Benkeser D, Alford-Teaster J, Haas JS, Tosteson AN, Hill D, Shi X, Henderson LM, Hubbard RA. Travel Burden to Breast MRI and Utilization: Are Risk and Sociodemographics Related? J Am Coll Radiol. 2016 Jun;13(6):611-9. doi: 10.1016/j.jacr.2016.01.022. Epub 2016 Mar 22. [View AbstractExternal Web Site Policy]

Onega T, Beaber EF, Sprague BL, Barlow WE, Haas JS, Tosteson AN, D Schnall M, Armstrong K, Schapira MM, Geller B, Weaver DL, Conant EF. Breast cancer screening in an era of personalized regimens: a conceptual model and National Cancer Institute initiative for risk-based and preference-based approaches at a population level. Cancer. 2014 Oct 1;120(19):2955-64. doi: 10.1002/cncr.28771. Epub 2014 May 15. Review. [View AbstractExternal Web Site Policy]

Sprague BL, Arao RF, Miglioretti DL, Henderson LM, Buist DS, Onega T, Rauscher GH, Lee JM, Tosteson AN, Kerlikowske K, Lehman CD; Breast Cancer Surveillance Consortium. National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology. 2017 Apr;283(1):59-69. doi: 10.1148/radiol.2017161519. Epub 2017 Feb 28. [View AbstractExternal Web Site Policy]

Sprague BL, Conant EF, Onega T, Garcia MP, Beaber EF, Herschorn SD, Lehman CD, Tosteson AN, Lacson R, Schnall MD, Kontos D, Haas JS, Weaver DL, Barlow WE; PROSPR Consortium. Variation in Mammographic Breast Density Assessments Among Radiologists in Clinical Practice: A Multicenter Observational Study. Ann Intern Med. 2016 Oct 4;165(7):457-464. doi: 10.7326/M15-2934. Epub 2016 Jul 19. [View AbstractExternal Web Site Policy]

Sprague BL, Stout NK, Schechter C, van Ravesteyn NT, Cevik M, Alagoz O, Lee CI, van den Broek JJ, Miglioretti DL, Mandelblatt JS, de Koning HJ, Kerlikowske K, Lehman CD, Tosteson AN. Benefits, harms, and cost-effectiveness of supplemental ultrasonography screening for women with dense breasts. Ann Intern Med. 2015 Feb 3;162(3):157-66. doi: 10.7326/M14-0692. [View AbstractExternal Web Site Policy]

Trentham-Dietz A, Kerlikowske K, Stout NK, Miglioretti DL, Schechter CB, Ergun MA, van den Broek JJ, Alagoz O, Sprague BL, van Ravesteyn NT, Near AM, Gangnon RE, Hampton JM, Chandler Y, de Koning HJ, Mandelblatt JS, Tosteson AN. Tailoring Breast Cancer Screening Intervals by Breast Density and Risk for Women Aged 50 Years or Older: Collaborative Modeling of Screening Outcomes. Ann Intern Med. 2016 Nov 15;165(10):700-712. doi: 10.7326/M16-0476. Epub 2016 Aug 23. [View AbstractExternal Web Site Policy]

Weiss JE, Goodrich M, Harris KA, Chicoine RE, Synnestvedt MB, Pyle SJ, Chen JS, Herschorn SD, Beaber EF, Haas JS, Tosteson AN, Onega T; PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) consortium. Challenges With Identifying Indication for Examination in Breast Imaging as a Key Clinical Attribute in Practice, Research, and Policy. J Am Coll Radiol. 2017 Feb;14(2):198-207.e2. doi: 10.1016/j.jacr.2016.08.017. Epub 2016 Oct 13. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: The Dartmouth Institute

Baughman AW, Brawarsky P, Onega T, Tosteson TD, Wang Q, Tosteson AN, Haas JS. Medical home transformation and breast cancer screening. Am J Manag Care. 2016 Nov 1;22(11):e382-e388. [View AbstractExternal Web Site Policy]

Bitton A, Onega T, Tosteson AN, Haas JS. Toward a better understanding of patient-reported outcomes in clinical practice. Am J Manag Care. 2014 Apr;20(4):281-3. Review. [View AbstractExternal Web Site Policy]

Clark CR, Tosteson TD, Tosteson AN, Onega T, Weiss JE, Harris KA, Haas JS. Diffusion of digital breast tomosynthesis among women in primary care:Cancer Med associations with insurance type. Cancer Med. 2017 May;6(5):1102-1107. doi: 10.1002/cam4.1036. Epub 2017 Apr 4. [View AbstractExternal Web Site Policy]

Haas JS, Baer HJ, Eibensteiner K, Klinger EV, St Hubert S, Getty G, Brawarsky P, Orav EJ, Onega T, Tosteson AN, Bates DW, Colditz G. A Cluster Randomized Trial of a Personalized Multi-Condition Risk Assessment in Primary Care. Am J Prev Med. 2017 Jan;52(1):100-105. doi: 10.1016/j.amepre.2016.07.013. Epub 2016 Sep 14. [View AbstractExternal Web Site Policy]

Haas JS, Kaplan CP. The Divide Between Breast Density Notification Laws and Evidence-Based Guidelines for Breast Cancer Screening: Legislating Practice. JAMA Intern Med. 2015 Sep;175(9):1439-40. doi: 10.1001/jamainternmed.2015.3040. [View AbstractExternal Web Site Policy]

Lacson R, Harris K, Brawarsky P, Tosteson TD, Onega T, Tosteson AN, Kaye A, Gonzalez I, Birdwell R, Haas JS. Evaluation of an Automated Information Extraction Tool for Imaging Data Elements to Populate a Breast Cancer Screening Registry. J Digit Imaging. 2015 Oct;28(5):567-75. doi: 10.1007/s10278-014-9762-4. [View AbstractExternal Web Site Policy]

Mandelblatt JS, Tosteson AN, van Ravesteyn NT. Costs, evidence, and value in the Medicare program: the challenges of technology innovation in breast cancer prevention and control. JAMA Intern Med. 2013 Feb 11;173(3):227-8. doi: 10.1001/jamainternmed.2013.2127. [View AbstractExternal Web Site Policy]

Murray MF, Giovanni MA, Klinger E, George E, Marinacci L, Getty G, Brawarsky P, Rocha B, Orav EJ, Bates DW, Haas JS. Comparing electronic health record portals to obtain patient-entered family health history in primary care. J Gen Intern Med. 2013 Dec;28(12):1558-64. doi: 10.1007/s11606-013-2442-0. Epub 2013 Apr 16. [View AbstractExternal Web Site Policy]

Onega T, Haas JS, Bitton A, Brackett C, Weiss J, Goodrich M, Harris K, Pyle S, Tosteson AN. Alignment of breast cancer screening guidelines, accountability metrics, and practice patterns. Am J Manag Care. 2017 Jan;23(1):35-40. [View AbstractExternal Web Site Policy]

Tosteson AN, Fryback DG, Hammond CS, Hanna LG, Grove MR, Brown M, Wang Q, Lindfors K, Pisano ED. Consequences of false-positive screening mammograms. JAMA Intern Med. 2014 Jun;174(6):954-61. doi: 10.1001/jamainternmed.2014.981. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: University of Pennsylvania

Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D. The Impact of Acquisition Dose on Quantitative Breast Density Estimation with Digital Mammography: Results from ACRIN PA 4006. Radiology. 2016 Sep;280(3):693-700. doi: 10.1148/radiol.2016151749. Epub 2016 Mar 22. [View AbstractExternal Web Site Policy]

Chudgar AV, Conant EF, Weinstein SP, Keller BM, Synnestvedt M, Yamartino P, McDonald ES. Assessment of disease extent on contrast-enhanced MRI in breast cancer detected at digital breast tomosynthesis versus digital mammography alone. Clin Radiol. 2017 Jul;72(7):573-579. doi: 10.1016/j.crad.2017.02.013. Epub 2017 Mar 17. [View AbstractExternal Web Site Policy]

Conant EF, Keller BM, Pantalone L, Gastounioti A, McDonald ES, Kontos D. Agreement between Breast Percentage Density Estimations from Standard-Dose versus Synthetic Digital Mammograms: Results from a Large Screening Cohort Using Automated Measures. Radiology. 2017 Jun;283(3):673-680. doi: 10.1148/radiol.2016161286. Epub 2017 Jan 25. [View AbstractExternal Web Site Policy]

Conant EF. Clinical implementation of digital breast tomosynthesis. Radiol Clin North Am. 2014 May;52(3):499-518. doi: 10.1016/j.rcl.2013.11.013. Epub 2014 Feb 18. Review. [View AbstractExternal Web Site Policy]

Daye D, Keller B, Conant EF, Chen J, Schnall MD, Maidment AD, Kontos D. Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure: a preliminary study in a high-risk population. Acad Radiol. 2013 May;20(5):635-46. doi: 10.1016/j.acra.2012.12.016. [View AbstractExternal Web Site Policy]

Gastounioti A, Oustimov A, Keller BM, Pantalone L, Hsieh MK, Conant EF, Kontos D. Breast parenchymal patterns in processed versus raw digital mammograms: A large population study toward assessing differences in quantitative measures across image representations. Med Phys. 2016 Nov;43(11):5862. [View AbstractExternal Web Site Policy]

Gastounioti A, Conant EF, Kontos D. Beyond breast density: a review on the advancing role of parenchymal texture analysis in breast cancer risk assessment. Breast Cancer Res. 2016 Sep 20;18(1):91. doi: 10.1186/s13058-016-0755-8. Review. [View AbstractExternal Web Site Policy]

Keller BM, Chen J, Daye D, Conant EF, Kontos D. Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: comparison of fully automated area and volumetric density measures in a case-control study with digital mammography. Breast Cancer Res. 2015 Aug 25;17:117. doi: 10.1186/s13058-015-0626-8. [View AbstractExternal Web Site Policy]

Keller BM, Oustimov A, Wang Y, Chen J, Acciavatti RJ, Zheng Y, Ray S, Gee JC, Maidment AD, Kontos D. Parenchymal texture analysis in digital mammography: robust texture feature identification and equivalence across devices. J Med Imaging (Bellingham). 2015 Apr;2(2):024501. doi: 10.1117/1.JMI.2.2.024501. Epub 2015 Apr 3. [View AbstractExternal Web Site Policy]

Keller BM, McCarthy AM, Chen J, Armstrong K, Conant EF, Domchek SM, Kontos D. Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography. BMC Cancer. 2015 Mar 18;15:143. doi: 10.1186/s12885-015-1159-3. [View AbstractExternal Web Site Policy]

Keller BM, Nathan DL, Gavenonis SC, Chen J, Conant EF, Kontos D. Reader variability in breast density estimation from full-field digital mammograms: the effect of image postprocessing on relative and absolute measures. Acad Radiol. 2013 May;20(5):560-8. doi: 10.1016/j.acra.2013.01.003. Epub 2013 Mar 5. [View AbstractExternal Web Site Policy]

Keller BM, Chen J, Conant EF, Kontos D. Breast density and parenchymal texture measures as potential risk factors for Estrogen-Receptor positive breast cancer. Proc SPIE Int Soc Opt Eng. 2014 Mar 27;9035:90351D. [View AbstractExternal Web Site Policy]

Keller BM, Nathan DL, Wang Y, Zheng Y, Gee JC, Conant EF, Kontos D. Estimation of breast percent density in raw and processed full field digital mammography images via adaptive fuzzy c-means clustering and support vector machine segmentation. Med Phys. 2012 Aug;39(8):4903-17. doi: 10.1118/1.4736530. [View AbstractExternal Web Site Policy]

Korhonen KE, Weinstein SP, McDonald ES, Conant EF. Strategies to Increase Cancer Detection: Review of True-Positive and False-Negative Results at Digital Breast Tomosynthesis Screening. Radiographics. 2016 Nov-Dec;36(7):1954-1965. Epub 2016 Oct 7. Review. [View AbstractExternal Web Site Policy]

McCarthy AM, Keller BM, Pantalone LM, Hsieh MK, Synnestvedt M, Conant EF, Armstrong K, Kontos D. Racial Differences in Quantitative Measures of Area and Volumetric Breast Density. J Natl Cancer Inst. 2016 Apr 29;108(10). doi: 10.1093/jnci/djw104. Print 2016 Oct. [View AbstractExternal Web Site Policy]

McCarthy AM, Yamartino P, Yang J, Bristol M, Conant EF, Armstrong K. Racial differences in false-positive mammogram rates: results from the ACRIN Digital Mammographic Imaging Screening Trial (DMIST). Med Care. 2015 Aug;53(8):673-8. doi: 10.1097/MLR.0000000000000393. [View AbstractExternal Web Site Policy]

McCarthy AM, Yang J, Armstrong K. Increasing disparities in breast cancer mortality from 1979 to 2010 for US black women aged 20 to 49 years. Am J Public Health. 2015 Jul;105 Suppl 3:S446-8. doi: 10.2105/AJPH.2014.302297. Epub 2015 Apr 23. [View AbstractExternal Web Site Policy]

McCarthy AM, Keller B, Kontos D, Boghossian L, McGuire E, Bristol M, Chen J, Domchek S, Armstrong K. The use of the Gail model, body mass index and SNPs to predict breast cancer among women with abnormal (BI-RADS 4) mammograms. Breast Cancer Res. 2015 Jan 8;17:1. doi: 10.1186/s13058-014-0509-4. [View AbstractExternal Web Site Policy]

McCarthy AM, Kontos D, Synnestvedt M, Tan KS, Heitjan DF, Schnall M, Conant EF. Screening outcomes following implementation of digital breast tomosynthesis in a general-population screening program. J Natl Cancer Inst. 2014 Oct 13;106(11). pii: dju316. doi: 10.1093/jnci/dju316. Print 2014 Nov. [View AbstractExternal Web Site Policy]

McCarthy AM, Armstrong K. The role of testing for BRCA1 and BRCA2 mutations in cancer prevention. JAMA Intern Med. 2014 Jul;174(7):1023-4. doi: 10.1001/jamainternmed.2014.1322. [View AbstractExternal Web Site Policy]

McDonald ES, McCarthy AM, Akhtar AL, Synnestvedt MB, Schnall M, Conant EF. Baseline Screening Mammography: Performance of Full-Field Digital Mammography Versus Digital Breast Tomosynthesis. AJR Am J Roentgenol. 2015 Nov;205(5):1143-8. doi: 10.2214/AJR.15.14406. [View AbstractExternal Web Site Policy]

Percac-Lima S, Ashburner JM, McCarthy AM, Piawah S, Atlas SJ. Patient navigation to improve follow-up of abnormal mammograms among disadvantaged women. J Womens Health (Larchmt). 2015 Feb;24(2):138-43. doi: 10.1089/jwh.2014.4954. Epub 2014 Dec 18. [View AbstractExternal Web Site Policy]

Pertuz S, McDonald ES, Weinstein SP, Conant EF, Kontos D. Fully Automated Quantitative Estimation of Volumetric Breast Density from Digital Breast Tomosynthesis Images: Preliminary Results and Comparison with Digital Mammography and MR Imaging. Radiology. 2016 Apr;279(1):65-74. doi: 10.1148/radiol.2015150277. Epub 2015 Oct 21. [View AbstractExternal Web Site Policy]

Ray S, Chen L, Keller BM, Chen J, Conant EF, Kontos D. Association between Breast Parenchymal Complexity and False-Positive Recall From Digital Mammography Versus Breast Tomosynthesis: Preliminary Investigation in the ACRIN PA 4006 Trial. Acad Radiol. 2016 Aug;23(8):977-86. doi: 10.1016/j.acra.2016.02.019. Epub 2016 May 25. [View AbstractExternal Web Site Policy]

Roth RG, Maidment AD, Weinstein SP, Roth SO, Conant EF. Digital breast tomosynthesis: lessons learned from early clinical implementation. Radiographics. 2014 Jul-Aug;34(4):E89-102. doi: 10.1148/rg.344130087. [View AbstractExternal Web Site Policy]

Seitz HH, Gibson L, Skubisz C, Forquer H, Mello S, Schapira MM, Armstrong K, Cappella JN. Effects of a risk-based online mammography intervention on accuracy of perceived risk and mammography intentions. Patient Educ Couns. 2016 Oct;99(10):1647-56. doi: 10.1016/j.pec.2016.05.005. Epub 2016 May 4. [View AbstractExternal Web Site Policy]

Zheng Y, Keller BM, Ray S, Wang Y, Conant EF, Gee JC, Kontos D. Parenchymal texture analysis in digital mammography: A fully automated pipeline for breast cancer risk assessment. Med Phys. 2015 Jul;42(7):4149-60. doi: 10.1118/1.4921996. [View AbstractExternal Web Site Policy]

Zuckerman SP, Conant EF, Keller BM, Maidment AD, Barufaldi B, Weinstein SP, Synnestvedt M, McDonald ES. Implementation of Synthesized Two-dimensional Mammography in a Population-based Digital Breast Tomosynthesis Screening Program. Radiology. 2016 Dec;281(3):730-736. Epub 2016 Jul 28. [View AbstractExternal Web Site Policy

Single Site Studies
Lead PROSPR Site: University of Vermont

Ahern TP, Sprague BL, Bissell MCS, Miglioretti DL, Buist DSM, Braithwaite D, Kerlikowske K. Family History of Breast Cancer, Breast Density, and Breast Cancer Risk in a U.S. Breast Cancer Screening Population. Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):938-944. doi: 10.1158/1055-9965.EPI-16-0801. Epub 2017 Jan 17. [View AbstractExternal Web Site Policy]

Bolton KC, Mace JL, Vacek PM, Herschorn SD, James TA, Tice JA, Kerlikowske K, Geller BM, Weaver DL, Sprague BL. Changes in breast cancer risk distribution among Vermont women using screening mammography. J Natl Cancer Inst. 2014 Jun 23;106(8). pii: dju157. doi: 10.1093/jnci/dju157. Print 2014 Aug. [View AbstractExternal Web Site Policy]

Berkman AM, Trentham-Dietz A, Dittus K, Hart V, Vatovec CM, King JG, James TA, Lakoski SG, Sprague BL. Health behavior change following a diagnosis of ductal carcinoma in situ: An opportunity to improve health outcomes. Prev Med. 2015 Nov;80:53-9. doi: 10.1016/j.ypmed.2015.03.020. Epub 2015 Apr 6. [View AbstractExternal Web Site Policy]

Berkman A, F Cole B, Ades PA, Dickey S, Higgins ST, Trentham-Dietz A, Sprague BL, Lakoski SG. Racial differences in breast cancer, cardiovascular disease, and all-cause mortality among women with ductal carcinoma in situ of the breast. Breast Cancer Res Treat. 2014 Nov;148(2):407-13. doi: 10.1007/s10549-014-3168-3. Epub 2014 Oct 18. [View AbstractExternal Web Site Policy]

Carney PA, Allison KH, Oster NV, Frederick PD, Morgan TR, Geller BM, Weaver DL, Elmore JG. Identifying and processing the gap between perceived and actual agreement in breast pathology interpretation. Mod Pathol. 2016 Jul;29(7):717-26. doi: 10.1038/modpathol.2016.62. Epub 2016 Apr 8. [View AbstractExternal Web Site Policy]

Cevik M, Ergun MA, Stout NK, Trentham-Dietz A, Craven M, Alagoz O. Using Active Learning for Speeding up Calibration in Simulation Models. Med Decis Making. 2016 Jul;36(5):581-93. doi: 10.1177/0272989X15611359. Epub 2015 Oct 15. [View AbstractExternal Web Site Policy]

Frederick PD, Nelson HD, Carney PA, Brunyé TT, Allison KH, Weaver DL, Elmore JG. The Influence of Disease Severity of Preceding Clinical Cases on Pathologists' Medical Decision Making. Med Decis Making. 2017 Jan;37(1):91-100. Epub 2016 Apr 1. [View AbstractExternal Web Site Policy]

Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, Johnson JM, Chicoine RE, Herschorn SD, Shepherd JA, Wang J, Malkov S, Vacek PM, Weaver DL, Fan B, Mahmoudzadeh AP, Palakal M, Xiang J, Oh H, Horne HN, Sprague BL, Hewitt SM, Brinton LA, Sherman ME. Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities. Cancer Prev Res (Phila). 2016 Feb;9(2):149-58. doi: 10.1158/1940-6207.CAPR-15-0282. Epub 2015 Dec 8. [View AbstractExternal Web Site Policy]

Hart V, Sprague BL, Lakoski SG, Hampton JM, Newcomb PA, Gangnon RE, Trentham-Dietz A. Trends in Health-Related Quality of Life After a Diagnosis of Ductal Carcinoma In Situ. J Clin Oncol. 2016 Apr 20;34(12):1323-9. doi: 10.1200/JCO.2015.62.7281. Epub 2016 Feb 16. Erratum in: J Clin Oncol. 2016 Aug 20;34(24):2943. [View AbstractExternal Web Site Policy]

Hart V, Reeves KW, Sturgeon SR, Reich NG, Sievert LL, Kerlikowske K, Ma L, Shepherd J, Tice JA, Mahmoudzadeh AP, Malkov S, Sprague BL. The effect of change in body mass index on volumetric measures of mammographic density. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1724-30. doi: 10.1158/1055-9965.EPI-15-0330. Epub 2015 Aug 27. [View AbstractExternal Web Site Policy]

Henderson LM, Hubbard RA, Sprague BL, Zhu W, Kerlikowske K. Increased Risk of Developing Breast Cancer after a False-Positive Screening Mammogram. Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1882-9. doi: 10.1158/1055-9965.EPI-15-0623. [View AbstractExternal Web Site Policy]

Henderson LM, Miglioretti DL, Kerlikowske K, Wernli KJ, Sprague BL, Lehman CD. Breast Cancer Characteristics Associated With Digital Versus Film-Screen Mammography for Screen-Detected and Interval Cancers. AJR Am J Roentgenol. 2015 Sep;205(3):676-84. doi: 10.2214/AJR.14.13904. [View AbstractExternal Web Site Policy]

James TA, Wade JE, Sprague BL. The impact of mammographic screening on the surgical management of breast cancer. J Surg Oncol. 2016 Apr;113(5):496-500. doi: 10.1002/jso.24184. Epub 2016 Jan 22. [View AbstractExternal Web Site Policy]

Johnson A, Shulman L, Kachajian J, Sprague BL, Khan F, James T, Cranmer D, Young P, Heimann R. Access to Care in Vermont: Factors Linked With Time to Chemotherapy for Women With Breast Cancer-A Retrospective Cohort Study. J Oncol Pract. 2016 Sep;12(9):e848-57. doi: 10.1200/JOP.2016.013409. Epub 2016 Aug 30. [View AbstractExternal Web Site Policy]

Kemp Jacobsen K, O'Meara ES, Key D, S M Buist D, Kerlikowske K, Vejborg I, Sprague BL, Lynge E, von Euler-Chelpin M. Comparing sensitivity and specificity of screening mammography in the United States and Denmark. Int J Cancer. 2015 Nov 1;137(9):2198-207. doi: 10.1002/ijc.29593. Epub 2015 Jun 1. [View AbstractExternal Web Site Policy]

Kemp Jacobsen K, Abraham L, Buist DS, Hubbard RA, O'Meara ES, Sprague BL, Kerlikowske K, Vejborg I, Von Euler-Chelpin M, Njor SH. Comparison of cumulative false-positive risk of screening mammography in the United States and Denmark. Cancer Epidemiol. 2015 Aug;39(4):656-63. doi: 10.1016/j.canep.2015.05.004. Epub 2015 May 23. [View AbstractExternal Web Site Policy]

Kerlikowske K, Gard CC, Sprague BL, Tice JA, Miglioretti DL. Breast Cancer Surveillance Consortium. One versus Two Breast Density Measures to Predict 5- and 10-Year Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2015 Jun;24(6):889-97. doi: 10.1158/1055-9965.EPI-15-0035. Epub 2015 Mar 30. [View AbstractExternal Web Site Policy]

Khadanga S, Lakoski SG, Hart V, Sprague BL, Ba Y, Hampton JM, Higgins ST, Ades PA, Newcomb PA, Trentham-Dietz A. Partnership Status and Socioeconomic Factors in Relation to Health Behavior Changes after a Diagnosis of Ductal Carcinoma In Situ Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):76-82. doi: 10.1158/1055-9965.EPI-15-0726. Epub 2015 Nov 6. [View AbstractExternal Web Site Policy]

Lee AY, Ichikawa L, Lee JM, Lee CI, DeMartini WB, Joe BN, Wernli KJ, Sprague BL, Herschorn SD, Lehman CD. Concordance of BI-RADS Assessments and Management Recommendations for Breast MRI in Community Practice. AJR Am J Roentgenol. 2016 Jan;206(1):211-6. doi: 10.2214/AJR.15.14356. [View AbstractExternal Web Site Policy]

Leopold RB, Thomas AW, Concannon KF, Correll AD, LaPenta CM, Maurer SM, Sprague BL, Herschorn SD, Verschraegen CF. Breast cancer screening in patients with cancers other than breast. Breast Cancer Res Treat. 2017 Jun;163(2):343-348. doi: 10.1007/s10549-017-4179-7. Epub 2017 Mar 6. [View AbstractExternal Web Site Policy]

McLaughlin VH, Trentham-Dietz A, Hampton JM, Newcomb PA, Sprague BL. Lifestyle factors and the risk of a second breast cancer after ductal carcinoma in situ. Cancer Epidemiol Biomarkers Prev. 2014 Mar;23(3):450-60. doi: 10.1158/1055-9965.EPI-13-0899. Epub 2014 Jan 8. [View AbstractExternal Web Site Policy]

Miglioretti DL, Lange J, van den Broek JJ, Lee CI, van Ravesteyn NT, Ritley D, Kerlikowske K, Fenton JJ, Melnikow J, de Koning HJ, Hubbard RA. Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study. Ann Intern Med. 2016 Feb 16;164(4):205-14. doi: 10.7326/M15-1241. Epub 2016 Jan 12. [View AbstractExternal Web Site Policy]

Nelson HD, O'Meara ES, Kerlikowske K, Balch S, Miglioretti D. Factors Associated With Rates of False-Positive and False-Negative Results From Digital Mammography Screening: An Analysis of Registry Data. Ann Intern Med. 2016 Feb 16;164(4):226-35. doi: 10.7326/M15-0971. Epub 2016 Jan 12. [View AbstractExternal Web Site Policy]

Othman E, Wang J, Sprague BL, Rounds T, Ji Y, Herschorn SD, Wood ME. Comparison of false positive rates for screening breast magnetic resonance imaging (MRI) in high risk women performed on stacked versus alternating schedules. Springerplus. 2015 Feb 13;4:77. doi: 10.1186/s40064-015-0793-1. eCollection 2015. [View AbstractExternal Web Site Policy]

Persing S, Jerome MA, James TA, Callas P, Mace J, Sowden M, Goodwin A, Weaver DL, Sprague BL. Surgical margin reporting in breast conserving surgery: Does compliance with guidelines affect re-excision and mastectomy rates? Breast. 2015 Oct;24(5):618-22. doi: 10.1016/j.breast.2015.06.007. Epub 2015 Jul 18. [View AbstractExternal Web Site Policy]

Samples LS, Rendi MH, Frederick PD, Allison KH, Nelson HD, Morgan TR, Weaver DL, Elmore JG. Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast. 2017 Aug;34:34-43. doi: 10.1016/j.breast.2017.04.004. Epub 2017 May 3. [View AbstractExternal Web Site Policy]

Shiyanbola OO, Sprague BL, Hampton JM, Dittus K, James TA, Herschorn S, Gangnon RE, Weaver DL, Trentham-Dietz A. Emerging trends in surgical and adjuvant radiation therapies among women diagnosed with ductal carcinoma in situ. Cancer. 2016 Sep 15;122(18):2810-8. doi: 10.1002/cncr.30105. Epub 2016 May 31. [View AbstractExternal Web Site Policy]

Sprague BL, Gangnon RE, Hampton JM, Egan KM, Titus LJ, Kerlikowske K, Remington PL, Newcomb PA, Trentham-Dietz A. Variation in Breast Cancer-Risk Factor Associations by Method of Detection: Results From a Series of Case-Control Studies. Am J Epidemiol. 2015 Jun 15;181(12):956-69. doi: 10.1093/aje/kwu474. Epub 2015 May 5. [View AbstractExternal Web Site Policy]

Sprague BL, Gangnon RE, Burt V, Trentham-Dietz A, Hampton JM, Wellman RD, Kerlikowske K, Miglioretti DL. Prevalence of mammographically dense breasts in the United States. J Natl Cancer Inst. 2014 Sep 12;106(10). pii: dju255. doi: 10.1093/jnci/dju255. Print 2014 Oct. [View AbstractExternal Web Site Policy]

Sprague BL, Bolton KC, Mace JL, Herschorn SD, James TA, Vacek PM, Weaver DL, Geller BM. Registry-based study of trends in breast cancer screening mammography before and after the 2009 U.S. Preventive Services Task Force recommendations. Radiology. 2014 Feb;270(2):354-61. doi: 10.1148/radiol.13131063. Epub 2013 Oct 28. [View AbstractExternal Web Site Policy]

Sprague BL, McLaughlin V, Hampton JM, Newcomb PA, Trentham-Dietz A. Disease-free survival by treatment after a DCIS diagnosis in a population-based cohort study. Breast Cancer Res Treat. 2013 Aug;141(1):145-54. doi: 10.1007/s10549-013-2670-3. Epub 2013 Aug 25. [View AbstractExternal Web Site Policy]

Tice JA, Miglioretti DL, Li CS, Vachon CM, Gard CC, Kerlikowske K. Breast Density and Benign Breast Disease: Risk Assessment to Identify Women at High Risk of Breast Cancer. J Clin Oncol. 2015 Oct 1;33(28):3137-43. doi: 10.1200/JCO.2015.60.8869. Epub 2015 Aug 17. [View AbstractExternal Web Site Policy]

Vatovec C, Erten MZ, Kolodinsky J, Brown P, Wood M, James T, Sprague BL. Ductal carcinoma in situ: a brief review of treatment variation and impacts on patients and society. Crit Rev Eukaryot Gene Expr. 2014;24(4):281-6. Review. [View AbstractExternal Web Site Policy]

Veal CT, Hart V, Lakoski SG, Hampton JM, Gangnon RE, Newcomb PA, Higgins ST, Trentham-Dietz A, Sprague BL. Health-related behaviors and mortality outcomes in women diagnosed with ductal carcinoma in situ. J Cancer Surviv. 2017 Jun;11(3):320-328. doi: 10.1007/s11764-016-0590-z. Epub 2017 Jan 5. [View AbstractExternal Web Site Policy]

Colorectal Cancer

Multi-Site Studies

Burnett-Hartman AN, Mehta SJ, Zheng Y, Ghai NR, McLerran DF, Chubak J, Quinn VP, Skinner CS, Corley DA, Inadomi JM, Doubeni CA; PROSPR Consortium. Racial/Ethnic Disparities in Colorectal Cancer Screening Across Healthcare Systems. Am J Prev Med. 2016 Oct;51(4):e107-15. doi: 10.1016/j.amepre.2016.02.025. Epub 2016 Apr 1. [View AbstractExternal Web Site Policy]

Chubak J, Garcia MP, Burnett-Hartman AN, Zheng Y, Corley DA, Halm EA, Singal AG, Klabunde CN, Doubeni CA, Kamineni A, Levin TR, Schottinger JE, Green BB, Quinn VP, Rutter CM; PROSPR consortium. Time to Colonoscopy after Positive Fecal Blood Test in Four U.S. Health Care Systems. Cancer Epidemiol Biomarkers Prev. 2016 Feb;25(2):344-50. doi: 10.1158/1055-9965.EPI-15-0470. [View AbstractExternal Web Site Policy]

Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME. Challenges and possible solutions to colorectal cancer screening for the underserved. J Natl Cancer Inst. 2014 Apr;106(4):dju032. doi: 10.1093/jnci/dju032. Epub 2014 Mar 28. Review. [View AbstractExternal Web Site Policy]

Klabunde CN, Zheng Y, Quinn VP, Beaber EF, Rutter CM, Halm EA, Chubak J, Doubeni CA, Haas JS, Kamineni A, Schapira MM, Vacek PM, Garcia MP, Corley DA; PROSPR consortium. Influence of Age and Comorbidity on Colorectal Cancer Screening in the Elderly. Am J Prev Med. 2016 Sep;51(3):e67-75. doi: 10.1016/j.amepre.2016.04.018. Epub 2016 Jun 22. [View AbstractExternal Web Site Policy]

Singal AG, Gupta S, Lee J, Halm EA, Rutter CM, Corley D, Inadomi J. Importance of determining indication for colonoscopy: implications for practice and policy original. Clin Gastroenterol Hepatol. 2014 Dec;12(12):1958-63.e1-3. Review. [View AbstractExternal Web Site Policy]

Tiro JA, Kamineni A, Levin TR, Zheng Y, Schottinger JS, Rutter CM, Corley DA, Skinner CS, Chubak J, Doubeni CA, Halm EA, Gupta S, Wernli KJ, Klabunde C. The colorectal cancer screening process in community settings: a conceptual model for the population-based research optimizing screening through personalized regimens consortium. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1147-58. doi: 10.1158/1055-9965.EPI-13-1217. Epub 2014 Jun 10. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: Group Health Cooperative

Adams KF, Johnson EA, Chubak J, Kamineni A, Doubeni CA, Buist DS, Williams AE, Weinmann S, Doria-Rose VP, Rutter CM. Development of an Algorithm to Classify Colonoscopy Indication from Coded Health Care Data. EGEMS (Wash DC). 2015 May 18;3(1):1171. doi: 10.13063/2327-9214.1171. eCollection 2015. [View AbstractExternal Web Site Policy]

Chubak J, Hubbard R. Defining and measuring adherence to cancer screening. J Med Screen. 2016 Dec;23(4):179-185. Epub 2016 Mar 4. [View AbstractExternal Web Site Policy]

Chubak J, Hubbard RA, Johnson E, Kamineni A, Rutter CM. Assessing the effectiveness of a cancer screening test in the presence of another screening modality. J Med Screen. 2015 Jun;22(2):69-75. doi: 10.1177/0969141314562036. Epub 2014 Dec 9. [View AbstractExternal Web Site Policy]

Green BB, Coronado GD, Devoe JE, Allison J. Navigating the murky waters of colorectal cancer screening and health reform. Am J Public Health. 2014 Jun;104(6):982-6. doi: 10.2105/AJPH.2014.301877. Epub 2014 Apr 17. [View AbstractExternal Web Site Policy]

Hubbard RA, Johnson E, Chubak J, Wernli KJ, Kamineni A, Bogart A, Rutter CM. "Accounting for misclassification in electronic health records-derived exposures using generalized linear finite mixture models. Health Serv Outcomes Res Methodol. 2017 Jun;17(2):101-112. doi: 10.1007/s10742-016-0149-5. Epub 2016 Jun 3. [View AbstractExternal Web Site Policy]

Hubbard R, Chubak J, Rutter C. Estimating screening test utilization using electronic health records data. EGEMS (Wash DC). 2014 Nov 4;2(1):14. [View AbstractExternal Web Site Policy]

Johnson KE, Kamineni A, Fuller S, Olmstead D, Wernli KJ. How the provenance of electronic health record data matters for research: a case example using system mapping. EGEMS (Wash DC). 2014 Apr 16;2(1):1058. doi: 10.13063/2327-9214.1058. eCollection 2014. [View AbstractExternal Web Site Policy]

Rutter CM, Greenlee RT, Johnson E, Stark A, Weinmann S, Kamineni A, Adams K, Doubeni CA. Prevalence of colonoscopy before age 50. Prev Med. 2015 Mar;72:126-9. doi: 10.1016/j.ypmed.2014.12.028. Epub 2015 Jan 4. [View AbstractExternal Web Site Policy]

Shortreed SM, Johnson E, Rutter CM, Kamineni A, Wernli KJ, Chubak J. Cohort restriction based on prior enrollment: Examining potential biases in estimating cancer and mortality risk. Obs Stud. 2016 Aug;2:51-64. Epub 2016 Sep 26. [View AbstractExternal Web Site Policy]

Wernli KJ, Brenner AT, Rutter CM, Inadomi JM. Risks Associated With Anesthesia Services During Colonoscopy. Gastroenterology. 2016 Apr;150(4):888-94; quiz e18. doi: 10.1053/j.gastro.2015.12.018. Epub 2015 Dec 18. [View AbstractExternal Web Site Policy]

Wernli KJ, Hubbard RA, Johnson E, Chubak J, Kamineni A, Green BB, Rutter CM. Patterns of colorectal cancer screening uptake in newly eligible men and women. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1230-7. doi: 10.1158/1055-9965.EPI-13-1360. Epub 2014 May 3. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: University of Texas Southwestern Medical Center

Elmunzer BJ, Singal AG, Sussman JB, Deshpande AR, Sussman DA, Conte ML, Dwamena BA, Rogers MA, Schoenfeld PS, Inadomi JM, Saini SD, Waljee AK. Comparing the effectiveness of competing tests for reducing colorectal cancer mortality: a network meta-analysis. Gastrointest Endosc. "2015 Mar;81(3):700-709.e3. doi: 10.1016/j.gie.2014.10.033. [View AbstractExternal Web Site Policy]

Gupta S, Sun H, Yi S, Storm J, Xiao G, Balasubramanian BA, Zhang S, Ashfaq R, Rockey DC. Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study. Cancer Prev Res (Phila). 2014 Oct;7(10):1023-34. doi: 10.1158/1940-6207.CAPR-14-0140. Epub 2014 Aug 4. [View AbstractExternal Web Site Policy]

Gupta S, Halm EA, Rockey DC, Hammons M, Koch M, Carter E, Valdez L, Tong L, Ahn C, Kashner M, Argenbright K, Tiro J, Geng Z, Pruitt S, Skinner CS. Comparative effectiveness of fecal immunochemical test outreach, colonoscopy outreach, and usual care for boosting colorectal cancer screening among the underserved: a randomized clinical trial. JAMA Intern Med. 2013 Oct 14;173(18):1725-32. [View AbstractExternal Web Site Policy]

Gupta S, Tong L, Anderson P, Rose B, Carter E, Koch M, Argenbright K, Ahn C, Allison J, Skinner CS. Measurement of colorectal cancer test use with medical claims data in a safety-net health system. Am J Med Sci. 2013 Feb;345(2):99-103. doi: 10.1097/MAJ.0b013e31824dd1b6. [View AbstractExternal Web Site Policy]

Gupta S, Balasubramanian BA, Fu T, Genta RM, Rockey DC, Lash R. Polyps with advanced neoplasia are smaller in the right than in the left colon: implications for colorectal cancer screening. Clin Gastroenterol Hepatol . 2012 Dec;10(12):1395-1401.e2. doi: 10.1016/j.cgh.2012.07.004. Epub 2012 Jul 24. [View AbstractExternal Web Site Policy]

Kahn B, Freeland Z, Gopal P, Agrawal D, Mayorga CA, Mithani R, Skinner CS, Halm EA, Singal AG. Predictors of guideline concordance for surveillance colonoscopy recommendations in patients at a safety-net health system. Cancer Causes Control. 2015 Nov;26(11):1653-60. doi: 10.1007/s10552-015-0661-x. Epub 2015 Sep 16. [View AbstractExternal Web Site Policy]

Marquez E, Geng Z, Pass S, Summerour P, Robinson L, Sarode V, Gupta S. Implementation of routine screening for Lynch syndrome in university and safety-net health system settings: successes and challenges. Genet Med. 2013 Dec;15(12):925-32. doi: 10.1038/gim.2013.45. Epub 2013 Apr 18. [View AbstractExternal Web Site Policy]

Martin J, Halm EA, Tiro JA, Merchant Z, Balasubramanian BA, McCallister K, Sanders JM, Ahn C, Bishop WP, Singal AG. Reasons for Lack of Diagnostic Colonoscopy After Positive Result on Fecal Immunochemical Test in a Safety-Net Health System. Am J Med. 2017 Jan;130(1):93.e1-93.e7. doi: 10.1016/j.amjmed.2016.07.028. Epub 2016 Aug 31. [View AbstractExternal Web Site Policy]

Murphy CC, Vernon SW, Diamond PM, Tiro JA. Competitive testing of health behavior theories: how do benefits, barriers, subjective norm, and intention influence mammography behavior? Ann Behav Med. 2014 Feb;47(1):120-9. doi: 10.1007/s12160-013-9528-0. [View AbstractExternal Web Site Policy]

Patel N, Tong L, Ahn C, Singal AG, Gupta S. Post-polypectomy Guideline Adherence: Importance of Belief in Guidelines, Not Guideline Knowledge or Fear of Missed Cancer. Dig Dis Sci. 2015 Oct;60(10):2937-45. doi: 10.1007/s10620-015-3685-x. Epub 2015 May 7. Review. [View AbstractExternal Web Site Policy]

Pruitt SL, Leonard T, Zhang S, Schootman M, Halm EA, Gupta S. Physicians, clinics, and neighborhoods: multiple levels of influence on colorectal cancer screening. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1346-55. doi: 10.1158/1055-9965.EPI-13-1130. Epub 2014 Apr 14. [View AbstractExternal Web Site Policy]

Singal AG, Gupta S, Skinner CS, Ahn C, Santini NO, Agrawal D, Mayorga CA, Murphy C, Tiro JA, McCallister K, Sanders JM, Bishop WP, Loewen AC, Halm EA. Effect of Colonoscopy Outreach vs Fecal Immunochemical Test Outreach on Colorectal Cancer Screening Completion: A Randomized Clinical Trial. JAMA. 2017 Sep 5;318(9):806-815. doi: 10.1001/jama.2017.11389. [View AbstractExternal Web Site Policy]

Singal AG, Gupta S, Tiro JA, Skinner CS, McCallister K, Sanders JM, Bishop WP, Agrawal D, Mayorga CA, Ahn C, Loewen AC, Santini NO, Halm EA. Outreach invitations for FIT and colonoscopy improve colorectal cancer screening rates: A randomized controlled trial in a safety-net health system. Cancer. 2016 Feb 1;122(3):456-63. doi: 10.1002/cncr.29770. Epub 2015 Nov 4. [View AbstractExternal Web Site Policy]

Skinner CS, Ahn C, Halm EA, Bishop WP, McCallister K, Sanders JM, Farrell D, Santini N, Singal AG. Recommendation of colorectal cancer testing among primary care patients younger than 50 with elevated risk. Prev Med. 2017 Sep;102:20-23. doi: 10.1016/j.ypmed.2017.06.014. Epub 2017 Jun 15. [View AbstractExternal Web Site Policy]

Skinner CS, Gupta S, Halm EA, Wright S, McCallister K, Bishop W, Santini N, Mayorga C, Agrawal D, Moran B, Sanders JM, Singal AG. Development of the Parkland-UT Southwestern Colonoscopy Reporting System (CoRS) for evidence-based colon cancer surveillance recommendations. J Am Med Inform Assoc. 2016 Mar;23(2):402-6. doi: 10.1093/jamia/ocv081. Epub 2015 Aug 8. [View AbstractExternal Web Site Policy]

Single Site Studies
Lead PROSPR Site: Kaiser Foundation Research Institute Northern California

Atkins L, Hunkeler EM, Jensen CD, Michie S, Lee JK, Doubeni CA, Zauber AG, Levin TR, Quinn VP, Corley DA. Factors influencing variation in physician adenoma detection rates: a theory-based approach for performance improvement. Gastrointest Endosc. 2016 Mar;83(3):617-26.e2. doi: 10.1016/j.gie.2015.08.075. Epub 2015 Sep 11. [View AbstractExternal Web Site Policy]

Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014 Apr 3;370(14):1298-306. doi: 10.1056/NEJMoa1309086. [View AbstractExternal Web Site Policy]

Corley DA, Jensen CD, Marks AR, Zhao WK, de Boer J, Levin TR, Doubeni C, Fireman BH, Quesenberry CP. Variation of adenoma prevalence by age, sex, race, and colon location in a large population: implications for screening and quality programs. Clin Gastroenterol Hepatol. 2013 Feb;11(2):172-80. doi: 10.1016/j.cgh.2012.09.010. Epub 2012 Sep 14. [View AbstractExternal Web Site Policy]

Doubeni CA. The impact of colorectal cancer screening on the US population: is it time to celebrate? Cancer. 2014 Sep 15;120(18):2810-3. doi: 10.1002/cncr.28789. Epub 2014 Jun 3. [View AbstractExternal Web Site Policy]

Doubeni CA, Jensen CD, Fedewa SA, Quinn VP, Zauber AG, Schottinger JE, Corley DA, Levin TR. Fecal Immunochemical Test (FIT) for Colon Cancer Screening: Variable Performance with Ambient Temperature. J Am Board Fam Med. 2016 11/12;29(6):672-681. doi: 10.3122/jabfm.2016.06.160060. [View AbstractExternal Web Site Policy]

Doubeni CA, Corley DA, Zauber AG. Colorectal Cancer Health Disparities and the Role of US Law and Health Policy. Gastroenterology. 2016 May;150(5):1052-1055. doi: 10.1053/j.gastro.2016.03.012. Epub 2016 Mar 24. [View AbstractExternal Web Site Policy]

Fedewa SA, Corley DA, Jensen CD, Zhao W, Goodman M, Jemal A, Ward KC, Levin TR, Doubeni CA. Colorectal Cancer Screening Initiation After Age 50 Years in an Organized Program. Am J Prev Med. 2017 Sep;53(3):335-344. doi: 10.1016/j.amepre.2017.02.018. Epub 2017 Apr 17. [View AbstractExternal Web Site Policy]

Jensen CD, Corley DA, Quinn VP, Doubeni CA, Zauber AG, Lee JK, Zhao WK, Marks AR, Schottinger JE, Ghai NR, Lee AT, Contreras R, Klabunde CN, Quesenberry CP, Levin TR, Mysliwiec PA. Fecal Immunochemical Test Program Performance Over 4 Rounds of Annual Screening: A Retrospective Cohort Study. Ann Intern Med. 2016 Apr 5;164(7):456-63. doi: 10.7326/M15-0983. Epub 2016 Jan 26. [View AbstractExternal Web Site Policy]

Jensen CD, Doubeni CA, Quinn VP, Levin TR, Zauber AG, Schottinger JE, Marks AR, Zhao WK, Lee JK, Ghai NR, Schneider JL, Fireman BH, Quesenberry CP, Corley DA. Adjusting for patient demographics has minimal effects on rates of adenoma detection in a large, community-based setting. Clin Gastroenterol Hepatol. 2015 Apr;13(4):739-46. doi: 10.1016/j.cgh.2014.10.020. Epub 2014 Oct 25. [View AbstractExternal Web Site Policy]

Lee A, Jensen CD, Marks AR, Zhao WK, Doubeni CA, Zauber AG, Quinn VP, Levin TR, Corley DA. Endoscopist fatigue estimates and colonoscopic adenoma detection in a large community-based setting. Gastrointest Endosc. 2017 Mar;85(3):601-610.e2. doi: 10.1016/j.gie.2016.09.033. Epub 2016 Oct 1. [View AbstractExternal Web Site Policy]

Lee JK, Corley DA. What makes a "good" colonoscopy quality indicator? Gastrointest Endosc. 2016 Jan;83(1):179-81. doi: 10.1016/j.gie.2015.06.052. [View AbstractExternal Web Site Policy]

Lee JK, Jensen CD, Lee A, Doubeni CA, Zauber AG, Levin TR, Zhao WK, Corley DA. Development and validation of an algorithm for classifying colonoscopy indication. Gastrointest Endosc. 2015 Mar;81(3):575-582.e4. doi: 10.1016/j.gie.2014.07.031. Epub 2015 Jan 8. [View AbstractExternal Web Site Policy]

Lee JK, Liles EG, Bent S, Levin TR, Corley DA. Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis. Ann Intern Med. 2014 Feb 4;160(3):171. doi: 10.7326/M13-1484. Review. [View AbstractExternal Web Site Policy]

Lee JK, Levin TR, Corley DA. The road ahead: what if gastroenterologists were accountable for preventing colorectal cancer? Clin Gastroenterol Hepatol. 2013 Mar;11(3):204-7. doi: 10.1016/j.cgh.2012.12.014. Review. [View AbstractExternal Web Site Policy]

Levin TR. The importance of choosing colorectal cancer screening tests: comment on "Adherence to colorectal cancer screening.” Arch Intern Med. 2012 Apr 9;172(7):582-3. doi: 10.1001/archinternmed.2012.349. [View AbstractExternal Web Site Policy]

Marks AR, Pietrofesa RA, Jensen CD, Zebrowski A, Corley DA, Doubeni CA. Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1692-8. doi: 10.1158/1055-9965.EPI-15-0559. Epub 2015 Sep 16. [View AbstractExternal Web Site Policy]

Meester RG, Zauber AG, Doubeni CA, Jensen CD, Quinn VP, Helfand M, Dominitz JA, Levin TR, Corley DA, Lansdorp-Vogelaar I. Consequences of Increasing Time to Colonoscopy Examination After Positive Result From Fecal Colorectal Cancer Screening Test. Clin Gastroenterol Hepatol. 2016 Oct;14(10):1445-1451.e8. doi: 10.1016/j.cgh.2016.05.017. Epub 2016 May 19. [View AbstractExternal Web Site Policy]

Meester RG, Doubeni CA, Zauber AG, Goede SL, Levin TR, Corley DA, Jemal A, Lansdorp-Vogelaar I. Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018. Cancer. 2015 Jul 1;121(13):2281-5. doi: 10.1002/cncr.29336. Epub 2015 Mar 12. [View AbstractExternal Web Site Policy]

Meester RG, Doubeni CA, Lansdorp-Vogelaar I, Jensen CD, van der Meulen MP, Levin TR, Quinn VP, Schottinger JE, Zauber AG, Corley DA, van Ballegooijen M. Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model. JAMA. 2015 Jun 16;313(23):2349-58. doi: 10.1001/jama.2015.6251. [View AbstractExternal Web Site Policy]

Meester RG, Doubeni CA, Lansdorp-Vogelaar I, Goede SL, Levin TR, Quinn VP, Ballegooijen Mv, Corley DA, Zauber AG. Colorectal cancer deaths attributable to nonuse of screening in the United States. Ann Epidemiol. 2015 Mar;25(3):208-213.e1. doi: 10.1016/j.annepidem.2014.11.011. Epub 2014 Dec 5. [View AbstractExternal Web Site Policy]

Zauber AG. The impact of screening on colorectal cancer mortality and incidence: has it really made a difference? Dig Dis Sci. 2015 Mar;60(3):681-91. doi: 10.1007/s10620-015-3600-5. Epub 2015 Mar 5. Review. [View AbstractExternal Web Site Policy]