Sandra A. Mitchell

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Dr. Sandra A. Mitchell is a Research Scientist and Program Director in the Outcomes Research Branch in the Healthcare Delivery Research Program. Her primary research interests focus on the measurement and management of symptoms, impairments in physical functioning, fatigue and comorbidity across the cancer control continuum. She has extensive experience in the collection, analysis, and interpretation of patient-generated health outcomes data in clinical trials, and advanced multivariate statistical analysis, with a particular methodologic interest in latent variable mixture modelling. Her scholarship also emphasizes cancer care delivery science, including dissemination and implementation of evidence-based interventions, clinical outcomes and quality measurement, and the use of health information technologies and decision support to improve care delivery and strengthen patient self-management. A board-certified Acute Care Nurse Practitioner, Dr. Mitchell maintains a clinical practice focusing on late effects and rehabilitation needs in long-term survivors of allogeneic hematopoietic stem cell transplantation, with a special emphasis on Chronic Graft-Versus-Host Disease.

Dr. Mitchell serves as the NCI Scientific Director for the development and testing of the National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), a new electronic patient-reported outcomes measurement system to integrate patient-reporting of symptomatic adverse events into cancer clinical trials. PRO-CTCAE integrates the patient perspective into adverse event reporting, and may ultimately prove useful as an outcome measure in comparative effectiveness research and to profile the severity and impact of therapy-related symptom burden in patients undergoing treatment for cancer.

Dr. Mitchell received her undergraduate and master’s degrees from the University of Toronto and the University of Rochester, and received a PhD from the University of Utah with a focus in quantitative methods. She is the author of numerous peer-reviewed publications in the areas of symptom management, cancer survivorship, measurement of physical function, and the application of patient-reported outcomes to evaluate treatment effects, including toxicity and therapeutic response. Dr. Mitchell’s work has been recognized with two NIH Clinical Center Director’s Awards, the Oncology Nursing Society’s Award for Excellence in Nursing-Sensitive Patient Outcomes, and the Relentless for a Cure Award from the Leukemia and Lymphoma Society. In October 2015, she will be inducted as a fellow of the American Academy of Nursing.