Current Projects Using SEER-MHOS Data

The following current projects are using SEER-MHOS data under data use agreements, shared with permission from the listed Principal Investigators.

Updated 30 October 2018

Project ID: 2018-078

Principal Investigator(s)
Calip, Gregory S
Project Title
Depression, daily physical activity and HRQOL among older adult patients with hematologic malignancies, breast cancer, and prostate cancer before and after diagnosis
Institution
University of Illinois at Chicago
Cancer Site(s)
Breast, Prostate, Lymphomas, Multiple myeloma, Leukemias, Non-Cancer
Aims
  1. Determine the prevalence of depression among older cancer survivors before and after cancer diagnosis. Further examine the difference in prevalence in the time periods before cancer diagnosis with the post cancer diagnosis period.
  2. Assess the level of daily physical activity measured through patient reported activities including lifting or carrying groceries, climbing flights of stairs, bending, kneeling, sitting, using toilet, eating, walking and bathing among older cancer survivors in the past 12-month period before and after cancer diagnosis. Further examine the difference in levels of physical activity in the time periods before cancer diagnosis with the post cancer diagnosis period.
  3. Examine health-related quality of life measured using VR-12 instrument among older cancer survivors in the past 24-month period before and after cancer diagnosis. In addition, inspect any difference in measured HRQOL values in the time spans before and after cancer diagnosis.

Project ID: 2018-076

Principal Investigator(s)
Younossi, Zobair
Project Title
Influence of Hepatocellular Carcinoma (HCC) on Health-Related Quality of Life
Institution
Department of Medicine at Inova Fairfax Hospital
Cancer Site(s)
Liver & bile duct
Aims
To prospectively identify changes in HRQol after diagnosis of HCC in comparison with a group of adults without HCC

Project ID: 2018-075

Principal Investigator(s)
Moss, Jennifer
Project Title
Urban/rural differences in HRQOL for Medicare enrollees with and without cancer
Institution
National Cancer Institute
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate, Non-Cancer
Aims

Hypothesis 1: HRQOL will be lower for SEER-MHOS participants in rural areas than in urban areas.

Hypothesis 2: HRQOL will be lower for SEER-MHOS cancer patients in rural areas than cancer patients in urban areas.

Hypothesis 3: The association between cancer status and HRQOL will vary by urbanicity, such that the negative relationship between cancer status and HRQOL will be larger in rural areas than in urban areas.

Exploratory Hypothesis 4: The associations among cancer status, urbanicity, and HRQOL will vary by race/ethnicity, such that racial/ethnic minority cancer patients living in rural areas will have the lowest HRQOL.

Project ID: 2018-074

Principal Investigator(s)
Burrell, Sherry
Project Title
Exploring Health Related Quality of Life in Cancer and Non-Cancer Patients in Medicare Managed Care
Institution
Villanova University
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate
Aims

Using data from cohorts of older adults a decade apart, Cohort 5 (2002-2004) and Cohort 15 (2012-2014), we will explore the following specific aims:

  1. To compare HRQOL at baseline between propensity-score matched cancer survivors and non-cancer participants within Cohorts 5 and 15.
  2. To compare HRQOL at baseline and 2-year follow-up between cancer survivors from Cohort 5 and Cohort 15.
  3. To explore relationships between patient demographic and clinical variables and HRQOL in cancer survivors from Cohort 5 and Cohort 15.
  4. To explore whether significant correlates of HRQOL at baseline serve as predictors of HRQOL at 2-year follow-up in Cohorts 5 and 15.

Project ID: 2018-073

Principal Investigator(s)
Arem, Hannah
Project Title
Prevalence and predictors of vitality/fatigue among breast, prostate and colorectal cancer survivors
Institution
George Washington University
Cancer Site(s)
Colorectal, Breast, Prostate
Aims
  1. We plan to assess prevalence of vitality/fatigue post-diagnosis and predictors of vitality/fatigue change from pre- to post-diagnosis among breast, prostate and colorectal cancer survivors in SEER-Medicare Health Outcomes Survey (MHOS).
  2. As a secondary outcome we will look at prevalence and predictors of changes in physical and mental summary scores for quality of life from pre- to post-diagnosis.

Project ID: 2018-72

Principal Investigator(s)
Torres-Harding, Susan / Ramthun, Megan
Project Title
The Effect of Prostate Cancer Treatments on the Prevalence of Depression and HRQoL
Institution
Roosevelt University
Cancer Site(s)
Prostate
Aims

Hypothesis 1. An ANOVA will be calculated to test hypothesis one, to determine if patients who undergo prostate brachytherapy will exhibit the highest rates of depression compared to the other two treatment groups with patients undergoing external beam radiation exhibiting the lowest scores. The independent variable will be prostate cancer treatment, and the dependent variable will positive screening of depression. My goal is to see whether various cancer treatment methods are more likely to put individuals at risk of depression.

Hypothesis 2. Second, an ANOVA will be calculated to test hypothesis two, to determine if patients who undergo prostate brachytherapy will exhibit the lowest scores of HRQoL compared to the three treatment groups with patients undergoing external beam radiation exhibiting the highest scores of HRQoL. The independent variable will be prostate cancer treatment, and the dependent variable will be the HRQoL rating.

Hypothesis 3. Third, a multiple regression will be calculated to test hypothesis three, to determine if older men have a decreased rate of depression compared to younger men and if African American men are at a greater risk of depression compared to men of other races. Age and race will be entered as independent variables, with the sample racial category being dummycoded in separate bi-level variables, using the methods outlined by Cohen, Cohen, West and Aiken (2003).

Hypothesis 4. Lastly, a mediation analysis will be calculated to test hypothesis four, to determine if the relationship between the prostate cancer treatment and depression is mediated by HRQoL. To conduct these analyses, guidelines provided by Frazier, Tix, and Barron (2004) will be used. First, the predictor (prostate cancer treatment) must predict the presumed outcome variable (depression). Second, the predictor variable (prostate cancer treatment) should have a statically significant relationship with the presume mediator (HRQoL). Third, the presumed mediator (HRQoL) must predict the outcome variable (depression). Finally, the analyses must demonstrate the relationship between the predictor (prostate cancer treatment) and outcome (depression) is nonsignificant/equivalent to zero when the mediator is added to the model (Frazier et al.).

Project ID: 2018-071

Principal Investigator(s)
He, Jinghua
Project Title
HRQOL in MAO patients with ten selected cancer types: A SEER-MHOS study
Institution
Merck & Co., Inc.
Cancer Site(s)
Oral cavity & pharynx, Liver & bile duct, Gallbladder & other billiary, Other digestive system, Lung & bronchus, Cervix, Uterus, Other female genital system, Endrocine sytem/Thyroid, Mesothelioma, Non-Cancer
Aims
  1. To describe the HRQOL distributions in SEER-MHOS patients diagnosed with the cancer of interest. All subscales scores and summary scores (based on SF-36 or VR-12) will be summarized, respectively. A health utility score (SF-6D/VR-6D) as an overall measure of health will also be calculated. The findings will be stratified by cancer stages if sample sizes permit, and survey time since diagnosis (every 6 months). Same analysis will be conducted in MHOS participants without cancer. The findings from the cancer free group will serve as a benchmark for the cancer group.
  2. To explore the associations between HRQOL and patient characteristics, including demographic factors (e.g., age, gender, race/ethnicity, marital status, household income, education level, geographic location), life style factors (e.g., smoking, BMI), and medical history (e.g., self- reported comorbidities, cancer stage and treatment modalities).

Project ID: 2017-070

Principal Investigator(s)
Bellizi, Keith
Project Title
Predicting health related quality of life and survival using patient reported geriatric assessment
Institution
University of Connecticut
Cancer Site(s)
Colorectal, Breast, Prostate
Aims

The current proposal aims to evaluate the potential prognostic value of using patient reported elements analogous to CGA domains from SEER-MHOS to predict quality of life and survival in older adults with cancer.

The overall goal of the proposed study is to develop a patient-reported geriatric assessment tool, mapping onto existing CGA domains and to examine the prognostic value of that tool on the health-related quality of life and overall survival of older cancer patients.

Research question 1: What is the relationship between self-reported geriatric assessment (individual domains and overall score) and overall survival among older adults with cancer?

Research question 2: What is the relationship between self-reported geriatric assessment (individual domains and overall score) and health-related quality of life (PCS, MCS) among older adults with cancer?

Project ID: 2017-069

Principal Investigator(s)
Rincon, Maria
Project Title
Trends in Disparity of Health-Related Quality of Life in Medicare Advantage Beneficiaries, 1998-2012
Institution
NCI
Cancer Site(s)
Oral cavity & pharynx, Esophagus, Stomach, Small intestine, Colorectal, Liver & bile duct, Gallbladder & other billiary, Pancreas, Other digestive system, Lung & bronchus, Nose, nasal cavity ... Larynx, Bones & joints, Soft tissue (incl. heart), Skin (excl. basal & squamous), Breast, Cervix, Uterus, Ovary, Other female genital system, Prostate, Other male genital system, Bladder, Kidney & renal pelvis, Urinary system, Eye & orbit, Brain & other nervous system, Endrocine sytem/Thyroid, Lymphomas, Multiple myeloma, Leukemias, Other acute leukemia, Mesothelioma, Kaposi's Sarcoma, Non-Cancer
Aims
  1. Examine disparity trends in physical and mental health status as a measure of health-related quality of life (HRQoL) among Medicare Advantage beneficiaries with and without a cancer history, by race/ethnicity.
  2. Examine disparity trends in physical and mental health status as measure of health-related quality of life (HRQoL) among Medicare Advantage beneficiaries with and without a cancer history, by highest level of education attained.
  3. Assess if disparity of HRQoL by race/ethnicity widens over the study time period (1998-2012).
  4. Assess if disparity of HRQoL by educational attainment widens over the study time period (1998-2012).

Project ID: 2017-068

Principal Investigator(s)
Siembida, Elizabeth
Project Title
Provision of physical activity recommendations among the young-old to oldest-old cancer survivors
Institution
NCI
Cancer Site(s)
Colorectal, Breast, Prostate
Aims

Aim 1: Compare the receipt of physical activity conversations with healthcare providers between older cancer survivors and their peers without a history of cancer.

Aim 2: Categorize older cancer survivors into age groups (young-old (65-69 years), older-old (70-80 years), and oldest-old (80+ years)), and compare frequencies of physical activity discussions between these groups.

Aim 3: Assess the interactions between chronological age and selfreported physical and mental health (PCS and MCS) and their impact on receipt of physical activity discussions with healthcare providers.

Aim 4: Assess the interactions between cancer history and selfreported physical and mental health (PCS and MCS) and their impact on receipt of physical activity discussions with healthcare providers.

Project ID: 2017-065

Principal Investigator(s)
Davidoff, Amy
Project Title
Patterns of Medication Therapy and Patient Reported Outcomes Associated with Pain and Depression
Institution
Yale University School of Public Health
Cancer Site(s)
Breast, Colorectal, Prostate, Lung, Bladder, Uterus, Melanoma, Lymphoma, Chronic leukemias (CML, CLL), and Myelodysplastic syndromes
Aims

Aim1 will involve descriptive analysis of patterns of pain and depression and changes in these symptoms between the first and second interview (for those with more than one interview), comparing beneficiaries with and without cancer.

Aim 2 analyses will begin with a description of patterns of medication therapy specific to reported pain and/or depression.

Aim 3 will examine whether medication therapy is associated with reduction or elimination of symptoms of pain and depression from the first to the second MHOS survey.

Aim 4 will examine whether symptoms of pain or depression are associated with adherence (duration and adherence, measured by medication possession ratio (MPR) to oral therapy, particularly hormone therapy for women diagnosed with breast cancer and who have initiated therapy.

Project ID: 2017-064

Principal Investigator(s)
Milano, Michael
Project Title
Long term outcomes in prostate cancer, lung cancer, and brain tumor patients
Institution
University of Rochester Medical Center, Department of Radiation Oncology
Cancer Site(s)
Lung & bronchus, Prostate, Brain & other nervous system
Aims
  1. In the population of primary brain tumors, we would like to examine patient functional status and cognition and correlation with treatment received, including surgery, radiation, and chemotherapy.
  2. For prostate cancer survivors, we intend to evaluate the incidence of, and modifying factors for, long-term outcomes after treatment of prostate cancer, with a focus on late gastrointestinal (GI), genitourinary (GU), and sexual toxicities.
  3. For survivors of early stage lung cancer, we would like to evaluate quality of life measures as well as respiratory status and chest pain after primary treatment.

Project ID: 2017-063

Principal Investigator(s)
Kumar, Anita J
Project Title
Assessment of Quality of Life and Health Outcomes in Patients with Hematologic Malignancies
Institution
Tufts Medical Center
Cancer Site(s)
Lymphomas, Multiple myeloma, Leukemias
Aims
  1. Aim 1: To describe demographics of elderly patients diagnosed with blood cancers between 2000-2013.
  2. Aim 2: To identify trends in health outcomes and quality of life among elderly patients with blood cancers between 2000-2014, stratified by disease (leukemia, lymphoma, myeloma). This will include 2 years of follow up for all patients diagnosed through 2012. We will compare these results to survey respondents without a cancer diagnosis.
  3. Aim 3: To identify the proportion of patients who have a change in their quality of life outcomes from diagnosis to 24 months after diagnosis.

Project ID: 2017-062

Principal Investigator(s)
Cress, Rosemary D
Project Title
Health Related Quality of Life in Older Women with Gynecological Cancer
Institution
Public Health Institute, Cancer Registry of Greater California
Cancer Site(s)
Cervix, Uterus, Ovary, Non-Cancer
Aims

Aim 1: To identify demographic, clinical, and functional factors associated with HRQOL among older women after diagnosis with gynecological cancer.

Aim 2: To evaluate factors associated with depressive symptoms among older women after diagnosis with gynecological cancer.

Aim 3: To determine the impact of diagnosis with gynecological cancer on HRQOL in older women.

Aim 4: To evaluate the effect of HRQOL on survival for older women with gynecological cancer.

Project ID: 2017-061

Principal Investigator(s)
Taioli, Emanuela
Project Title
Quality of life after surgery or radiation in stage I lung cancer patients
Institution
Icahn School of Medicine at Mount Sinai
Cancer Site(s)
Lung & bronchus
Aims
We hypothesize that early stage lung cancer treated with radiation yields better quality of life than if it is treated with surgery.

Project ID: 2017-060

Principal Investigator(s)
Sun, Virginia
Project Title
Functional Impairment and Health-Related QOL in Older Cancer Survivors After Surgical Procedures
Institution
City of Hope
Cancer Site(s)
Esophagus, Stomach, Colorectal, Liver & bile duct, Gallbladder & other billiary, Pancreas, Lung & bronchus
Aims
  1. To characterize functional impairments, multimorbidity, and health-related quality of life in older survivors of lung/bronchus and GI (esophagus, stomach, small intestine, colorectal, liver & bile duct, gallbladder & other biliary, pancreas, other digestive system) cancers who were surgically treated;
  2. To evaluate oncologic outcomes (overall survival, cancer-specific survival) of older cancer survivors who were surgically treated for lung/bronchus and GI cancers;
  3. To characterize the association of functional impairment and comorbidities on oncologic outcomes;
  4. To evaluate the effect of race/ethnicity and socioeconomic status on functional impairment, multimorbidity, HRQOL, and oncologic outcomes.

Project ID: 2017-059

Principal Investigator(s)
Pierorazio, Phillip M
Project Title
Self-reported QOL as a surrogate for death from competing risks in ptns with renal cell carcinoma
Institution
Johns Hopkins University School of Medicine
Cancer Site(s)
Prostate, Other male genital system, Bladder, Kidney & renal pelvis, Urinary system
Aims

Using SEER-MHOS, we seek to investigate self-reported quality of life in patients with renal cell carcinoma selecting surgical versus non-surgical management, and analyze its predictive ability on cancer-specific and overall survival.

Furthermore, we intend to compare and validate the results observed in the renal cell carcinoma population to patients with other genitourinary malignancies, like blagder, prostate, testis, etc.

Our hypothesis is that differences are likely to exist in the self-reported quality of life between patients who choose surgery versus non-surgical management and that self-reported quality of life questionnaires are a better measure of life expectancy/risk stratification than other metrics like the Charlson Comorbidity Index.

Project ID: 2013-021

Principal Investigator(s)
Alberts, David S
Project Title
Assessment of cancer clinical, economic and humanistic outcomes among underserved
Institution
University of Arizona Cancer Center
Cancer Site(s)
Esophagus, Stomach, Colorectal, Liver & bile duct, Breast, Cervix, Prostate, Non-Cancer
Aims
Assess the health-related quality of life (HRQOL) of underserved racial/ethnic populations that have been diagnosed with breast, cervical, colorectal, and prostate cancer.

Project ID: 2011-006

Principal Investigator(s)
Chen, Ronald
Project Title
Appropriateness of Aggressive Cancer Treatment Based on Life Expectancy
Institution
University of North Carolina at Chapel Hill
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate, Non-Cancer
Aims

"The goal of this study is to examine the patterns of aggressive cancer care in different patient strata by life expectancy. For many cancers, such as prostate cancer, aggressive treatment may involve surgery and/or multi-modality therapy. However, for older patients and those with comorbidities, often less aggressive treatment is pursued.

Using patient age and existing comorbidities prior to cancer diagnosis (which are available in the SEER-MHOS dataset (the investigators will categorize patients into different life expectancy groups. Then in each group, patterns of care in terms of treatments received will be examined. While patterns of care studies are common in the cancer literature, how patient life expectancy affects aggressiveness of cancer treatment is not a well-studied subject. The latter is the focus of this proposed study."

Project ID: 2015-042

Principal Investigator(s)
Clark, Clancy
Project Title
Health-related Quality for Life for Cancer Survivors Treated with Surgery (Revised)
Institution
Wake Forest Baptist Health
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate
Aims
  1. To investigate the feasibility of a study using the Surveillance, Epidemiology, and End Results- Medicare Health Outcomes Survey (SEER-MHOS) linked database to measure health-related quality of life in cancer survivors treated with an operation.
  2. To characterize the physical and mental health of patients diagnosed with cancer using a large population-based database.
  3. To compare self-reported physical and mental health between cancer survivors treated with and without surgical resection after controlling for age, race, socioeconomic status, co-morbidities, cancer histology, and cancer stage.
  4. To compare self-reported physical and mental health between cancer and noncancer patients after controlling for age, race, co-morbidities, and socioeconomic status.
  5. To examine disparities in cancer outcomes and its underlying attributes.

Project ID: 2016-049

Principal Investigator(s)
Cote, Michele L
Project Title
Impact of cancer diagnosis and treatment on HRQOL in Black and minority elderly women with GYN cancer
Institution
Wayne State University School of Medicine
Cancer Site(s)
Breast, Cervix, Uterus, Ovary
Aims
  1. To describe racial differences in self-reported HRQOL in women after gynecologic cancer diagnosis compared to propensity-matched non-cancer controls.
  2. To describe racial differences in self-reported HRQOL in gynecologic cancer patients compared to a cohort of breast cancer patients.
  3. To examine factors associated with poor HRQOL in women diagnosed with gynecologic cancer.

Project ID: 2016-055

Principal Investigator(s)
Duarte, Christine
Project Title
Prediction of Six Month Mortality in Cancer Patients
Institution
Maine Medical Center Research Institute
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate
Aims
  1. Measure the calibration and discrimination of the original PROMPT in the sample of SEER-linked cancer patients for the top four cancers (breast, prostate, lung, and colorectal).
  2. Using the SEER variables in addition to the MHOS data, develop a cancer-specific model to predict six month mortality in the four most prevalent cancers, first for combined cancer and then for each of the four cancers separately.

Project ID: 2015-045

Principal Investigator(s)
Friese, Chris
Project Title
Heart Failure in Women Who Survive Breast Cancer: Health-Related Quality of Life
Institution
University of Michigan School of Nursing
Cancer Site(s)
Breast
Aims

Aim 1. Compare 8 domains of HRQL among four groups of women age 65 and older: Group 1 (BrCa+HF): women with a history of breast cancer and HF; Group 2 (BrCa): women with a history of breast cancer but no history of HF; Group 3 (HF): women with HF but no history of cancer; Group 4 (NoCaHF): healthy women with no history of cancer or heart failure. To control for demographic and clinical variables, women in groups 2, 3, and 4 will be identified based on propensity score matching with women in group 1.25 Hypothesis 1. At two-year follow-up, women in the BrCa+HF group have the poorest HRQL in the following domains: physical functioning, general health, vitality, and mental health.

Aim 2. Among the four groups, compare how each of the 8 domains of HRQL changes over time, from baseline to two years later. Hypothesis 2. Over the two-year period, women in the BrCa+HF group have the greatest decline in HRQL in the domains of physical functioning, general health, vitality, and mental health.

Aim 3. For all women in the sample, determine the relationship between baseline HRQL and diagnosis status (breast cancer and HF diagnoses) and HRQL at two-year follow-up in each of the 8 domains. Hypothesis 3. Baseline HRQL and diagnoses of breast cancer and HF predict HRQL at two years.

Project ID: 2015-039

Principal Investigator(s)
Huang, Min
Project Title
Impact of cancer on health-related QoL, ADLs, and falls in older Medicare Beneficiaries
Institution
University of Michigan-Flint
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Uterus, Prostate, Bladder, Kidney & renal pelvis, Lymphomas
Aims
  1. To examine the changes in HRQOL, prevalence in limitations in ADLs, problems with balance or walking, fall risk management, and falls after the cancer diagnosis in older cancer survivors.
  2. To evaluate the relationship between cancer-related clinical variables, HRQOL, ADLs, balance or walking, and falls in cancer survivors after their cancer diagnosis.
  3. To identify among variables at baseline, including cancer-related clinical variables, HRQOL, limitations in ADLs, problems with balance or walking, fall risk management, and the previous history of falls, the unique factors predictive of falls in older cancer survivors.
  4. Develop evidence-based clinical algorithms to optimize the outcomes including problems with balance or walking as well as falls in older cancer survivors.

Project ID: 2014-033

Principal Investigator(s)
Kenzik, Kelly
Project Title
Understanding multi-morbidity in cancer to enhance palliative and supportive care
Institution
University of Alabama at Birmingham
Aims
  1. Identify comorbidity clusters of multi-morbidities pre- and post- cancer diagnosis across cancer types.
  2. Determine the symptom burden associated with different multi-morbidity clusters among cancer patients.
  3. Determine the functional limitations associated with different multi-morbidity clusters among cancer patients.

Project ID: 2016-057

Principal Investigator(s)
Mehra, Saral
Project Title
Impact of Treatment for Head and Neck Cancer on Health Related Quality of Life
Institution
Yale University
Cancer Site(s)
Oral cavity & pharynx, Nose, Nasal cavity, Larynx, Endrocine sytem/Thyroid
Aims
  1. Patients completing a MHOS survey after initiation of treatment for HNC will have inferior HRQOL and ability to perform ADLs compared to patients completing a MHOS survey before initiation of treatment for HNC (see part 1 below).
  2. Differences in HRQOL and ability to perform ADLs in patients completing a MHOS survey before versus after initiation of treatment will be affected by tumor-, treatment and patient-specific variables, including specific tumor subsite (oral cavity, nasopharynx, oropharynx & tonsil, larynx & hypopharynx, and salivary gland) and the interval of time between treatment initiation and survey completion (see part 1 below).
  3. Patients completing a MHOS survey after initiation of treatment for thyroid cancer will have inferior HRQOL and ability to perform ADLs compared to patients completing a MHOS survey before initiation of treatment for thyroid cancer (see part 2 below).
  4. Differences in HRQOL and ability to perform ADLs before versus after initiation of treatment in patients with laryngeal or hypopharyngeal cancer will be affected by initial treatment modality (see part 3 below).
  5. Differences in HRQOL and ability to perform ADLs before versus after initiation of treatment in patients with oropharyngeal or tonsil cancer will be affected by initial treatment modality (see part 4 below).

Project ID: 2015-043

Principal Investigator(s)
Min, Hua
Project Title
Applying the Ontology-guided Machine Learning to analyze the SEER-MHOS Linked Database
Institution
George Mason University
Cancer Site(s)
Oral cavity & pharynx, Stomach, Colorectal, Pancreas, Lung & bronchus, Nose, Nasal cavity, Larynx, Skin (excl. basal & squamous), Breast, Uterus, Prostate, Bladder
Aims
Aim 1. Develop an ontology-guided ML method that allows for analyzing heterogeneous healthcare datasets.

Aim 2. Test the ontology-guided ML method to analyze the SEER-MHOS dataset.

Aim 3. Investigate the associations between the quality of life (QoL), survival, and other characteristics in patients with cancer.

Project ID: 2016-052

Principal Investigator(s)
Payakachat, Nalin
Project Title
Health-related Quality of Life among Older Americans with Cancers: A Population-based Study
Institution
University of Arkansas for Medical Sciences
Cancer Site(s)
Oral cavity & pharynx, Lung & bronchus, Cervix, Uterus, Ovary, Other female genital system, Bladder, Kidney & renal pelvis, Urinary system, Multiple myeloma
Aims

Specific Aim 1: Compare HRQoL and health utility changes among selected cancer patients across disease stages and type of cancer from before to after cancer diagnosis with matched non-cancer controls.

Specific Aim 2: Assess HRQoL and health utility changes among selected cancer patients across initial course of treatment from before to after cancer diagnosis with matched non-cancer controls.

Specific Aim 3: Determine HRQoL and health utility changes among selected cancer patients across race/ethnicity from before to after cancer diagnosis with matched non-cancer controls.

Project ID: 2015-037

Principal Investigator(s)
Reeve, Bryce B
Project Title
Changes in HRQOL among survivors of lung, prostate, bladder, and gynecological cancers
Institution
University of North Carolina
Cancer Site(s)
Lung & bronchus, Cervix, Uterus, Ovary, Other female genital system, Prostate, Bladder
Aims
  1. Examine changes in HRQoL from before to after cancer among Medicare Beneficiaries stratified by treatment type and burden of comorbid health conditions.
  2. Compare the impact of cancer, treatment type, and comorbid conditions on Medicare beneficiaries' lives relative to matched controls without cancer.
  3. Conduct in-depth analyses by cancer treatment type to examine clinical and sociodemographic factors that may be associated with HRQoL declines for Medicare beneficiaries with cancer.

Project ID: 2013-025

Principal Investigator(s)
Schade, George; Wright, Jonathan L
Project Title
Health Related Quality of Life Among Medicare Beneficiaries with Urological Malignancies
Institution
University of Washington, Dept. of Urology
Cancer Site(s)
Prostate, Bladder, Kidney & renal pelvis, Non-Cancer
Aims
  1. To determine the effect of different treatment approaches for common urologic malignancies (prostate, kidney and bladder) on patient reported HRQoL.
  2. To evaluate the change in patient reported HRQoL compared to healthy controls following diagnosis and treatment of bladder, kidney and prostate cancer.

Project ID: 2015-044

Principal Investigator(s)
Schade, George R.; Wright, Jonathan L
Project Title
Health Related Quality of Life Among Medicare Beneficiaries with Urological Malignancies (update)
Institution
University of Washington
Cancer Site(s)
Colorectal, Prostate, Bladder, Kidney & renal pelvis
Aims
Aim 1. To determine the effect of different treatment approaches for common urologic malignancies (prostate, kidney and non-muscle invasive bladder) on patient reported HRQoL.

Aim 2. To evaluate the change in patient reported HRQoL compared to healthy controls following diagnosis and treatment of non-muscle invasive bladder, kidney, and prostate cancer.

Aim 3. To assess the change in patient reported HRQoL of muscle invasive bladder cancer patients undergoing radical cystectomy with urinary diversion (ileal conduit) compared to colo-rectal cancer patients undergoing extirpative surgery with colostomy or ileostomy.

Project ID: 2016-053

Principal Investigator(s)
Tibbitts, Deanne
Project Title
Secular Trends in Health-Related Quality of Life Among Older Women with Breast Cancer, 1998-2013
Institution
National University of Natural Medicine
Cancer Site(s)
Breast, Non-Cancer
Aims

Specific Aim 1: To analyze secular trends in post-diagnosis HRQOL among OWBC from 1998-2013.

Hypothesis: Post-diagnosis HRQOL has improved among OWBC from 1998-2013.

Specific Aim 2: To analyze secular trends in changes in HRQOL during the pre- to post-diagnosis period from 1998-2013 among OWBC and to compare them to secular trends in changes in HRQOL from baseline to follow-up survey among older women without cancer.

Hypothesis: During the pre- to post-diagnosis period, changes in HRQOL among OWBC have decreased more than changes in HRQOL in the non-cancer population from 1998-2013.

Specific Aim 3: To analyze secular trends in differences in HRQOL between OWBC and matched, non-cancer controls from 1998-2013.

Hypothesis: Differences in HRQOL between OWBC and matched, non-cancer controls have decreased from 1998-2013.

Project ID: 2013-026

Principal Investigator(s)
Ware, John E.; Frendl, Daniel M
Project Title
Using Patient-Reported Data to Improve Treatment Decisions for Older Men With Prostate Cancer
Institution
University of Mass Medical School
Cancer Site(s)
Prostate
Aims
  1. To describe the patient factors associated with prostate cancer treatment allocation (aggressive vs. conservative therapies) and to identify factors associated with patients dying of prostate cancer versus other causes of death.
  2. To identify predictors (patient factors, quality of life indicators, and information routinely collected in clinical practice) of 5- and 10-year other cause mortality among men with prostate cancer.
  3. To develop a risk calculator from risk prediction models using a subset of variables routinely available in clinical practice to predict 10-year risk of other cause mortality.
  4. Using the prediction scores derived from Specific Aim 2, to estimate the cost of evidenced-based, appropriately aggressive, care delivery vs. actual care received as reported in SEER, among men with prostate cancer, stratified across levels of other cause mortality risk.

Project ID: 2015-036

Principal Investigator(s)
Wildes, Tanya
Project Title
The Epidemiology of Multiple Myeloma
Institution
Washington University School of Medicine
Cancer Site(s)
Multiple myeloma
Aims
Retrospective data analyses to determine the associations of race, socioeconomic status (SES), comorbidities, etc. with multiple myeloma (MM) survival, MM treatment, healthcare utilization etc.

Project ID: 2016-054

Principal Investigator(s)
Wisnivesky, Juan
Project Title
Optimizing Treatment of Lung Cancer Patients with Comorbidities
Institution
Mount Sinai Health System
Cancer Site(s)
Lung & bronchus
Aims
  1. The LCPM can accurately represent the natural history, treatment, and outcomes of lung cancer patients with chronic lung, heart, and renal disease as well as by overall burden of comorbidities.
  2. Stage I NSCLC patients with severe comorbidities will benefit from less aggressive forms of therapy.
  3. Stage II and IIIA NSCLC patients with moderate to severe chronic lung, heart, or renal disease or with high burden of comorbidities will not benefit from adjuvant chemotherapy.
  4. Resection will lead to better outcomes than chemoradiotherapy in limited stage SCLC patients with severe renal disease or high burden of comorbidities.

Project ID: 2013-017

Principal Investigator(s)
Yu, James B
Project Title
Measuring and comparing the health utility of patients who have undergone modern cancer therapy
Institution
Yale School of Medicine
Cancer Site(s)
Colorectal, Lung & bronchus, Breast, Prostate, Non-Cancer
Aims
  1. Calculate the health utility of patients before and after cancer treatment, by converting the SF-36 data to a single health utility.
  2. Compare the impact of different cancer treatments on changes to health utility.
  3. Incorporate the impact of cancer treatment and its changes to a patient's measured health utility on modifying the measurement of comparative effectiveness that has been measured without incorporating health utility.

Project ID: 2016-050

Principal Investigator(s)
Yu, James B
Project Title
Measuring and comparing the health utility of patients who have undergone modern cancer therapy
Institution
Yale School of Medicine
Cancer Site(s)
Lung & bronchus, Breast, Prostate, Bladder, Non-Cancer
Aims

Specific Aim 1) Calculate the health utility of patients before and after cancer treatment, by converting the SF-36 data to a single health utility.

Specific Aim 2) Compare the impact of different cancer treatments on changes to health utility.

Specific Aim 3) To incorporate the impact of cancer treatment and its changes to a patient's measured health utility on modifying the measurement of comparative effectiveness that has been measured without incorporating health utility.