Module 10. Quantitative Analytic Techniques, Part 3

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Module 10. Quantitative Analytic Techniques, Part 3

Module Summary

• Mediation analysis
• Context, moderators
• Describe how theory influences quantitative methods

Reading Materials

• Baron, R.M. and Kenny, D.A., The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology. 1986; 51(6), p.1173.
• Morrissey, J. P., Lich, K. H., Price, R. A., & Mandleblat, J. Computational modeling and multilevel cancer control interventions. Journal of the National Cancer Institute Monographs, 2012; (44), 56-66.

Web Resources

• Center for Multilevel Modeling
• Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach, 3rd Ed
• David Kenny mediation website
• FDA guidance on co-primary endpoints
• Applied Multilevel Analysis (PDF)
• Longitudinal mediation models
• Mediation should be done even when there is no overall treatment effect
• Missing data website
• Analysis of partially observed clustered data using generalized estimating equations and multiple imputation.
• Weighted Methods for Analyzing Missing Data with the GEE Procedure (in SAS) (PDF)

Self-reflection Questions

• What type of quantitative research question are you trying to answer?
• What are you measuring, manipulating and/or controlling?
• What are you using for your dependent, independent, categorical, and continuous variables and how do they apply to the analytic methods?