Correspondence Between PRO-CTCAE and CTCAE Terminologies

PRO-CTCAE Symptom Terms and Corresponding CTCAE Terms

Oral

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Dry mouth	Dry mouth
Difficulty swallowing	Dysphagia
Mouth/throat sores	Mucositis oral
Cracking at the corners of the mouth (cheilosis/cheilitis)	Cheilitis
Voice quality changes	Voice alteration
Hoarseness	Hoarseness

Gastrointestinal

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Taste changes	Dysgeusia
Decreased appetite	Anorexia
Nausea	Nausea
Vomiting	Vomiting
Heartburn	Dyspepsia
Gas	Flatulence
Bloating	Bloating
Hiccups	Hiccups
Constipation	Constipation
Diarrhea	Diarrhea
Abdominal pain	Abdominal pain
Fecal incontinence	Fecal incontinence

Respiratory

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Shortness of breath	Dyspnea
Cough	Cough
Wheezing	Wheezing

Cardio/Circulatory

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Swelling	Edema limbs
Heart palpitations	Palpitations

Cutaneous

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Rash	Rash maculo-papular
Skin dryness	Dry skin
Acne	Rash acneiform
Hair loss	Alopecia
Itching	Pruritus
Hives	Urticaria
Hand-foot syndrome	Palmar-plantar erythrodysesthesia syndrome
Nail loss	Nail loss
Nail ridging	Nail ridging
Nail discoloration	Nail discoloration
Sensitivity to sunlight	Photosensitivity
Bed/pressure sores	Skin ulceration
Radiation skin reaction	Dermatitis radiation
Skin darkening	Skin hyperpigmentation
Stretch marks	Skin and subcutaneous tissue disorders – Other, specifiy: (Striae)

Neurological

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Numbness & tingling	Peripheral sensory neuropathy
Dizziness	Dizziness

Visual/Perceptual

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Blurred vision	Blurred vision
Flashing lights	Flashing lights
Visual floaters	Floaters
Watery eyes	Watering eyes
Ringing in ears	Tinnitus

Attention/Memory

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Concentration	Concentration impairment
Memory	Memory impairment

Pain

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
General Pain	Pain
Headache	Headache
Muscle pain	Myalgia
Joint pain	Arthralgia

Sleep/Wake

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Insomnia	Insomnia
Fatigue	Fatigue

Mood

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Anxious	Anxiety
Discouraged	Depression
Sad	Depression

Genitourinary

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Irregular periods/vaginal bleeding	Irregular menstruation
Missed expected menstrual period	Irregular menstruation
Vaginal discharge	Vaginal discharge
Vaginal dryness	Vaginal dryness
Painful urination	Urinary tract pain
Urinary urgenc	Urinary urgency
Urinary frequency	Urinary frequency
Change in usual urine color	Urine discoloration
Urinary incontinence	Urinary incontinence

Sexual

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Achieve and maintain erection	Erectile dysfunction
Ejaculation	Ejaculation disorder
Decreased libido	Libido decreased
Delayed orgasm	Delayed orgasm
Unable to have orgasm	Anorgasmia
Pain w/sexual intercourse	Dyspareunia

Miscellaneous

PRO-CTCAE Symptom Term	Corresponding CTCAE Version 5.0 Term
Breast swelling and tenderness	Gynecomastia (males) Breast pain (women)
Bruising	Bruising
Chills	Chills
Increased sweating	Hyperhidrosis
Decreased sweating	Hypohidrosis
Hot flashes	Hot flashes
Nosebleed	Epistaxis
Pain and swelling at injection site	Injection site reaction
Body odor	Body odor

Ped-PRO-CTCAE Symptom Terms and Corresponding CTCAE Terms

Oral

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Dry mouth	Dry mouth
Difficulty swallowing	Dysphagia
Mouth/throat sores	Mucositis oral
Voice quality changes	Voice alteration
Hoarseness	Hoarseness
Sore throat	Sore throat

Gastrointestinal

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Taste changes	Dysgeusia
Decreased appetite	Anorexia
Nausea	Nausea
Vomiting	Vomiting
Heartburn	Dyspepsia
Gas	Flatulence
Bloating	Bloating
Hiccups	Hiccups
Constipation	Constipation
Diarrhea	Diarrhea
Abdominal pain	Abdominal pain
Fecal incontinence	Fecal incontinence

Respiratory

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Shortness of breath	Dyspnea
Cough	Cough
Wheezing	Wheezing
Sneezing	Sneezing

Cardio/Circulatory

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Swelling	Edema limbs
Heart palpitations	Palpitations

Cutaneous

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Skin dryness	Dry skin
Acne	Rash acneiform
Hair loss	Alopecia
Itching	Pruritus
Hives	Urticaria
Sensitivity to sunlight	Photosensitivity
Skin ulceration	Skin ulceration

Neurological

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Numbness & tingling	Peripheral sensory neuropathy
Dizziness	Dizziness

Visual/Perceptual

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Blurred vision	Blurred vision
Flashing lights	Flashing lights
Watery eyes	Watering eyes
Ringing in ears	Tinnitus
Dry eyes	Dry eye

Attention/Memory

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Concentration	Concentration impairment
Memory	Memory impairment

Pain

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
General Pain	Pain
Headache	Headache
Muscle pain	Myalgia
Joint pain	Arthralgia

Sleep/Wake

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Insomnia	Insomnia
Fatigue	Fatigue

Mood

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Anxious	Anxiety
Sad	Depression
Suicidal ideation	Suicidal ideation

Genitourinary

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Painful urination	Urinary tract pain
Urinary urgenc	Urinary urgency
Urinary frequency	Urinary frequency
Change in usual urine color	Urine discoloration
Urinary incontinence	Urinary incontinence

Miscellaneous

PRO-CTCAE Symptom Term (Pediatric Module)	Corresponding CTCAE Version 5.0 Term
Bruising	Bruising
Chills	Chills
Increased sweating	Hyperhidrosis
Hot flashes	Hot flashes
Nosebleed	Epistaxis
Falls	Fall
Muscle weakness	Generalized muscle weakness
Restlessness	Akathisia

Last Updated: 26 Apr, 2023