Table Describing Changes in Codes for NCI Comorbidity Index

Condition 2000 Definition (ICD-9) 2014 Definition (ICD-9) 2021 Definition** (ICD-9) 2021 Definition** (ICD-10)
Acute Myocardial Infarction 410.xx with inpatient length of stay >2 days 410.xx with inpatient length of stay >2 days 410.x I21.x, I22.x
History of Myocardial Infarction 412.bb 412.bb 412.x I25.2
Congestive Heart Failure 428.xx 398.91, 425.4x-425.5x, 425.7x-425.9x, 428.xx 398.91, 402.01, 402.11, 402.91, 404.01, 404.03, 404.11, 404.13, 404.91, 404.93, 425.4–425.9, 428.x I09.9, I11.0, I13.0, I13.2, I25.5, I42.0, I42.5–I42.9, I43.x, I50.x, P29.0
Peripheral Vascular Disease 441.xx, 443.9x, 785.4x, V43.4x 093.0x, 440.xx-441.xx, 442.0x-442.8x, 443.1x-443.9x, 447.70-447.73, 785.4x, V43.4x 093.0, 440.x, 441.x, 443.1–443.9, 447.1, 557.1, 557.9, V43.4
Note: 437.3 is not included.		 I70.x, I71.x, I73.1, I73.8, I73.9, I77.1, I79.0, I79.2, K55.1, K55.8, K55.9, Z95.8, Z95.9
Procedure codes: 38.13, 38.14, 38.16, 38.18, 38.33, 38.34, 38.36, 38.38, 38.43, 38.44, 38.46, 38.48, 39.22-39.26, 39.28, 39.29 Procedure codes: 00.60, 38.13, 38.14, 38.15, 38.16, 38.18, 38.33, 38.34, 38.36, 38.38, 38.43, 38.44, 38.46, 38.48, 38.68, 39.25, 39.29    
HCPC: 35011, 35013, 35045, 35081, 35082, 35091, 35092, 35102, 35103, 35111, 35112, 35616, 35621, 35623, 35626, 35631, 35636, 35641, 35121, 35122, 35131, 35132, 35141, 35142, 35151, 35152, 35153, 35311, 35321, 35331, 35341, 35351, 35506, 35507, 35511, 35516, 35518, 35521, 35526, 35531, 35533, 35536, 35541, 35546, 35548, 35549, 35551, 35556, 35558, 35560, 35563, 35565, 35566, 35571, 35582, 35583, 35585, 35587, 35601, 35606, 35612, 35616, 35621, 35623, 35626, 35631, 35636, 35641, 35646, 35650, 35651, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 35694, 35695, 35355-35381      
Cerebrovascular Disease (CVD) 430.xx - 437.xx, 438.bb 430.xx- 438.xx 362.34, 430.x–438.x G45.x, G46.x, H34.0, I60.x–I69.x
Procedure codes: 38.12, 38.42 Procedure codes: 00.61, 00.62, 00.63, 00.65, 38.12, 38.32, 38.42, 39.22, 39.28, 39.74    
HCPC: 35301, 35001, 35002, 35005, 35501, 35508, 35509, 35515, 35642, 35645, 35691, 35693      
Chronic Obstructive Pulmonary Disease (COPD) 490.xx - 496.xx, 500.xx - 505.xx, 506.4x 416.8x-416.9x, 490.xx-496.xx, 500.xx-505.xx, 506.4x, 519.1x 416.8, 416.9, 490.x–505.x, 506.4, 508.1, 508.8 I27.8, I27.9, J40.x–J47.x, J60.x–J67.x, J68.4, J70.1, J70.3
Dementia 290.xx 290.xx, 291.0x-291.2x, 292.82, 294.1x, 331.0x-331.2x, 331.82 290.x, 294.1, 331.2 F00.x–F03.x, F05.1, G30.x, G31.1
Paralysis (Hemiplegia or Paraplegia) 342.xx, 344.1x 342.xx, 344.0x-344.6x, 344.9x 334.1, 342.x, 343.x, 344.0–344.6, 344.9 G04.1, G11.4, G80.1, G80.2, G81.x, G82.x, G83.0–G83.4, G83.9
Diabetes 250.bb, 250.0x - 250.3x, 250.7x 250.bb, 250.0x-250.3x 250.0–250.3, 250.8, 250.9 E10.0, E10.1, E10.6, E10.8, E10.9, E11.0, E11.1, E11.6, E11.8, E11.9, E13.0, E13.1, E13.6, E13.8, E13.9
Diabetes with Complications 250.4x - 250.6x, 250.8x -250.9x 250.4x-250.9x, 362.0x 250.4–250.7 E10.2–E10.5, E10.7, E11.2–E11.5, E11.7, E13.2–E13.5, E13.7
Renal Disease 582.xx-583.xx, 585.xx-586.xx, 588.xx 403.01, 403.11, 403.91, 404.02, 404.03, 404.12, 404.13, 404.92, 404.93, 582.xx-583.xx, 585.xx-586.xx, 588.xx, V42.0x, V45.1x, V56.xx 403.01, 403.11, 403.91, 404.02, 404.03, 404.12, 404.13, 404.92, 404.93, 582.x, 583.0–583.7, 585.x, 586.x, 588.0, V42.0, V45.1, V56.x I12.0, I13.1, N03.2–N03.7, N05.2–N05.7, N18.x, N19.x, N25.0, Z49.0–Z49.2, Z94.0, Z99.2
  Procedure codes: 39.27, 39.42, 39.95, 54.98, 55.69    
Mild Liver Disease 571.2x, 571.4x - 571.6x 070.32-070.33, 070.54, 571.2x, 571.4x-571.6x 070.22, 070.23, 070.32, 070.33, 070.44, 070.54, 070.6, 070.9, 570.x, 571.x, 573.3, 573.4, 573.8, 573.9, V42.7 B18.x, K70.0–K70.3, K70.9, K71.3–K71.5, K71.7, K73.x, K74.x, K76.0, K76.2–K76.4, K76.8, K76.9, Z94.4
Moderate/Severe Liver Disease 456.0x-456.1x, 456.2b, 456.20, 456.21, 572.2x-572.8x 070.22-070.23, 070.44, 456.0x-456.2x, 572.2x-572.8x, V42.7x 456.0–456.2, 572.2–572.8 I85.0, I85.9, I86.4, I98.2, K70.4, K71.1, K72.1, K72.9, K76.5, K76.6, K76.7
Procedure codes: 39.1b, 42.91 Procedure codes: 39.1b, 42.91, 50.5x    
HCPC: 37140, 37145, 37160, 37180, 37181, 75885, 75887, 43204, 43205      
Peptic Ulcer Disease ULCER1: 531.0x-531.3x, 532.0x-532.3x, 533.0x-533.3x, 534.0x-534.3x, 531.bx, 531.9x, 532.bx, 532.9x, 533.bx, 533.9x, 534.bx, 534.9x
ULCER2: 531.4x-531.7x, 532.4x-532.7x, 533.4x-533.7x, 534.4x-534.7x 		531.xx-534.xx 531.x–534.x K25.x–K28.x
Rheumatologic Disease 710.0b, 710.1b, 710.4b, 714.0x-714.2x, 714.81, 725.bb 710.0x, 710.1x, 710.4x, 714.0x-714.2x, 714.81, 725.bb 446.5, 710.0–710.4, 714.0–714.2, 714.8, 725.x M05.x, M06.x, M31.5, M32.x–M34.x, M35.1, M35.3, M36.0
AIDS 042.xx - 044.xx 042.xx-044.x, V08.bb, 795.71 042.x–044.x B20.x–B22.x, B24.x

Note: “b” denotes blank, “x” denotes any character including blank.

**Modified version Quan et al., Coding Algorithms for Defining Comorbidities in ICD-9-CM and ICD-10 Administrative Data, Med Care 2005;43: 1130–1139, which was based on Canadian codes. To make this algorithm applicable to U.S. data some codes were not included (i.e., E12 and E14 for diabetes).

Last Updated: 05 Sep, 2024